| Author | Diniz, Michely C. | |
| Author | Costa, Marcília P. | |
| Author | Pacheco, Ana C. L. | |
| Author | Kamimura, Michel T. | |
| Author | Silva, Samara C. | |
| Author | Carneiro, Laura D. G. | |
| Author | Sousa, Ana P. L. | |
| Author | Soares, Carlos E. A. | |
| Author | Souza, Celeste S. F. | |
| Access date | 2018-09-23T13:31:13Z | |
| Available date | 2018-09-23T13:31:13Z | |
| Document date | 2009 | |
| Citation | DINIZ, Michely C. et al. Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation. Genetics and Molecular Biology, v.32, n.3, p.652-665, 2009. | pt_BR |
| ISSN | 1415-4757 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28994 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Genética | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania | pt_BR |
| Subject in Portuguese | Fagossomos | pt_BR |
| Subject in Portuguese | proteínas flagelares | pt_BR |
| Subject in Portuguese | proteínas que interagem com actina | pt_BR |
| Title | Actin-interacting and flagellar proteins in Leishmania spp .: Bioinformatics predictions to functional assignments in phagosome formation | pt_BR |
| Type | Article | |
| Abstract | Severalmotileprocessesareresponsibleforthemovementofproteinsintoandwithintheflagellarmembrane,butlittle is known about the process by which specific proteins (either actin-associated or not) are targeted to protozoan flagellar membranes. Actin is a major cytoskeleton protein, while polymerization and depolymerization of parasite actin and actin-interacting proteins (AIPs) during both processes of motility and host cell entry might be key events for successful infection. For a better understanding the eukaryotic flagellar dynamics, we have surveyed genomes, transcriptomes and proteomes of pathogenic L eis h m a nia s p p . to identify pertinent genes/proteins and to build in silico models to properly address their putative roles in trypanosomatid virulence. In a search for AIPs involved in flagellar activities, we applied computational biology and proteomic tools to infer from the biological meaning of coroninsandArp2/3,twoimportantelementsinphagosomeformationafterparasitephagocytosisbymacrophages. Resultspresentedhereprovidethefirstreportof Leishmania coroninandArp2/3asflagellarproteinsthatalsomight be involved in phagosome formation through actin polymerization within the flagellar environment. This is an issue worthy of further in vit r o examination that remains now as a direct, positive bioinformatics-derived inference to be presented. | pt_BR |
| Affilliation | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Ceará. Núcleo Tarcísio Pimenta de Pesquisa Genômica e Bioinformática. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | actin-interacting proteins (AIPs) | pt_BR |
| Subject | flagellar proteins | pt_BR |
| Subject | Leishmania | pt_BR |
| Subject | coronin and Arp2/3 | pt_BR |
| Subject | phagosome | pt_BR |
| e-ISSN | 1678-4685 | |
