| Author | Alencar, Alba Cristina Miranda de Barros | |
| Author | Neves, Renata Heisler | |
| Author | Águila, Márcia Barbosa | |
| Author | Mandarim -de-Lacerda, Carlos Alberto | |
| Author | Gomes, Delir Corrêa | |
| Author | Silva, José Roberto Machado | |
| Access date | 2018-09-24T16:02:21Z | |
| Available date | 2018-09-24T16:02:21Z | |
| Document date | 2009 | |
| Citation | ALENCAR, Alba Cristina Miranda de Barros et al. High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 4, p. 608-613, July 2009. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29006 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Schistosoma mansoni | pt_BR |
| Subject in Portuguese | Colesterol | pt_BR |
| Subject in Portuguese | Fase crônica | pt_BR |
| Title | High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice | pt_BR |
| Type | Article | |
| DOI | 10.1590/S0074-02762009000400013 | |
| Abstract | This study investigated whether a long-term high-fat diet has an effect on the outcome of chronic murine schistosomiasis mansoni compared to a standard diet. Swiss Webster female mice (3 weeks old) were fed each diet for up to six months and were then infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring total serum cholesterol and body mass. Infected mice were examined 6-17 weeks post infection to estimate the number of eggs in faeces. Mice were euthanised the next day. Total serum cholesterol was lower in infected mice in comparison to uninfected controls (p = 0.0055). In contrast, body mass (p = 0.003), liver volume (p = 0.0405), spleen volume (p = 0.0124), lung volume (p = 0.0033) and faecal (p = 0.0064) and tissue egg density (p = 0.0002) were significantly higher for infected mice fed a high-fat diet. From these findings, it is suggested that a high-fat diet has a prominent effect on the course of chronic schistosomiasis mansoni in mice. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laborartório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Morfometria e Morfologia Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Morfometria e Morfologia Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Laborartório de Helmintologia Romero Lascasas Porto. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Schistosoma mansoni | pt_BR |
| Subject | Cholesterol | pt_BR |
| Subject | Chronic phase | pt_BR |
| e-ISSN | 1678-8060 | |
