| Author | Nunes, Fernanda Freire Campos | |
| Author | Santos, Marina Lima Silva | |
| Author | Kano, Flora Satiko | |
| Author | Fontes, Cor Jesus Fernandes | |
| Author | Lacerda, Marcus Vinícius Guimarães de | |
| Author | Brito, Cristiana Ferreira Alves de | |
| Author | Carvalho, Luzia Helena de | |
| Access date | 2018-09-25T14:24:24Z | |
| Available date | 2018-09-25T14:24:24Z | |
| Document date | 2013 | |
| Citation | NUNES, Fernanda Freire Campos et al. Genetic Variability in Platelet Integrin α2β1 Density: Possible Contributor to Plasmodium vivax–induced Severe Thrombocytopenia. Am J Trop Med Hyg., v. 88, n. 2, p. 325–328, 2013. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29040 | |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Plasmodium vivax | pt_BR |
| Subject in Portuguese | malaria | pt_BR |
| Title | Genetic Variability in Platelet Integrin α2β1 Density: Possible Contributor to Plasmodium vivax–induced Severe Thrombocytopenia | pt_BR |
| Type | Article | |
| DOI | 10.4269/ajtmh.2012.12-0297 | |
| Abstract | Understanding the pathogenesis of Plasmodium vivax malaria is challenging. We hypothesized that susceptibility to P. vivax-induced thrombocytopenia could be associated with polymorphisms on relevant platelet membrane integrins: integrin α2 (C807T), and integrin β3 (T1565C). Although β3 polymorphism was not related with P. vivax malaria, α2 807T carriers, which show high levels of integrin α2β1, had a higher probability for severe thrombocytopenia than wild-type carriers. This evidence of the association of integrin polymorphism and P. vivax morbidity was further demonstrated by a moderate but significant correlation between clinical disease and surface levels of the integrin α2β1. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Mato Grosso. Cuiabá, MT, Brazil | pt_BR |
| Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Plasmodium vivax | pt_BR |
| Subject | malaria | pt_BR |
| Embargo date | 2050-01-01 | |
