| Author | Coura, Renata dos | |
| Author | Marques, Christiane de Fátima Silva | |
| Author | Koifman, Rosalina J. | |
| Author | Koifman, Sergio | |
| Author | Cabello, Pedro Hernan | |
| Author | Hatagima, Ana | |
| Access date | 2018-09-26T16:33:44Z | |
| Available date | 2018-09-26T16:33:44Z | |
| Document date | 2007 | |
| Citation | COURA, Renata dos Santos; et al. CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population. Genetics and Molecular Biology, v.30,n.1, p.1-5, 2007. | pt_BR |
| ISSN | 1415-4757 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29078 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Genética | pt_BR |
| Rights | open access | |
| Subject in Portuguese | CYP2E1 | pt_BR |
| Subject in Portuguese | CYP1A1 | pt_BR |
| Subject in Portuguese | Citocromos | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population | pt_BR |
| Type | Article | |
| Abstract | The enzymes encoded by the polymorphic genes
CYP1A1
and
CYP2E1
play an important role in the activation and inactivationofxenobiotics.Theseenzymeshavebeenassociatedwithxenobiotic-induceddiseases,suchascancer, therapeutic failure and adverse effects of drugs. The aim of the present study was to determine the allelic and genotypic frequencies of these polymorphisms in a large, ethnically mixed Brazilian population sample from Rio de Janeiro.PolymorphismsCYP1A1andCYP2E1weredeterminedin870unrelatedindividualsbyPCR-RFLPanalysis inperipheralbloodDNA.Theobservedallelicfrequencieswere0.90for CYP1A1*1A and0.95for CYP2E1*1A ,inthe total sample. The allelic frequency of CYP1A1*2C in “pardos” (0.13) and Brazilian whites (0.11) was higher than in Caucasians(0.05),whichmaybearesultoftheAmerindiangeneticcomponent,thatpresentsthehighestfrequency of this allele observed up to now. The genotype distributions for both polymorphisms were in Hardy-Weinberg equilibrium and were statistically different between males and females, and among ethnic groups. | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Sul. Programa de Pós-graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro. RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Departamento de Epidemiologia e Métodos Quantitativos em Saúde. Rio de Janeiro. RJ, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | cytochromes P450 | pt_BR |
| Subject | CYP1A1 | pt_BR |
| Subject | CYP2E1 | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1678-4685 | |
