| Author | Villar, Livia Melo | |
| Author | Milagres, Flavio Augusto Pádua | |
| Author | Lampe, Elisabeth | |
| Author | Cruz, Helena Medina | |
| Author | Scalioni, Leticia de Paula | |
| Author | Magalhães, Mônica de Avelar Figueiredo Mafra | |
| Author | Romão, Anselmo Rocha | |
| Author | Carrijo, Renata de Saldanha da Gama Gracie | |
| Author | Paula, Vanessa Salete de | |
| Access date | 2018-09-30T15:31:58Z | |
| Available date | 2018-09-30T15:31:58Z | |
| Document date | 2018 | |
| Citation | VILLAR, Livia Melo et al. Determination of hepatitis B, C and D prevalence among urban and Amerindian populations from the Eastern Brazilian Amazon: a cross sectional study. BMC Infectious Diseases, v. 18, n. 411, p. 1-9, 2018. | en_US |
| ISSN | 1471-2334 | |
| URI | https://www.arca.fiocruz.br/handle/icict/29157 | |
| Language | eng | en_US |
| Publisher | BMC | en_US |
| Rights | open access | |
| Subject in Portuguese | Hepatite B | en_US |
| Subject in Portuguese | Hepatite C | en_US |
| Subject in Portuguese | Hepatite D | en_US |
| Subject in Portuguese | prevalência | en_US |
| Subject in Portuguese | Ameríndios | en_US |
| Subject in Portuguese | Norte de Brasil | en_US |
| Subject in Portuguese | Amazônia Oriental | en_US |
| Title | Determination of hepatitis B, C and D prevalence among urban and Amerindian populations from the Eastern Brazilian Amazon: a cross sectional study | en_US |
| Type | Article | |
| DOI | 10.1186/s12879-018-3279-2 | |
| Abstract | Background: This study was conducted to determine the prevalence of HBV, HCV, and HDV in urban populations and Amerindians living in the state of Tocantins (Eastern Amazon). Methods: A total of 948 individuals were recruited in Tocantinopolis city (Tocantins state) of whom 603 were Amerindians (from 6 tribes) and 345 were non-Amerindians (6 urban areas of Tocantinópolis city). Anti-HCV, HBsAg, antiHBc, anti-HBs, anti-HBc IgM, anti-HBe, HBeAg, and anti-delta antibodies were determined using enzyme immunoassay. Results: HBV cleared infection (both anti-HBc/anti-HBs+), chronic inactive/immune controlled HBV infection (anti-HBc + only), previous HBV vaccination (anti-HBs + only), active HBV infection (HBsAg+), individuals susceptible to HBV, and anti-HCV reactivity were found in 12.9, 1.8, 27.2, 0.5, 57.7, 1.2% in Amerindians and 12.1, 2.0, 37.1, 0.3, 55.4, 0.3% in nonAmerindians respectively. Out of 139 anti-HBc reactive individuals, 70 were anti-HBe reactive and none presented HBeAg or anti-HBc IgM. Anti-HBc prevalence was associated to older age (p < 0.0001). Overall anti-Delta prevalence was 0.3% and regarding anti-HBc reactive individuals, anti-delta prevalence was 3.4 and 0% in Amerindians and nonAmerindians respectively. Conclusions: Overall low prevalence of HBV and HCV infection was found in the populations studied, but high HBV and HCV prevalence was observed in Amerindians compared to non-Amerindians suggesting that these individuals have a higher likelihood of acquiring to these infections. Anti-delta antibodies were found among Amerindians from Eastern Amazon suggesting a risk for this population. Of note is that nearly half of Amerindians had no anti-HBs, indicating a need for HBV vaccination campaigns in this population. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Universidade Federal do Tocantins. PO, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saùde. Laboratório de Informação em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saùde. Laboratório de Informação em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saùde. Laboratório de Informação em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Hepatitis B | en_US |
| Subject | Hepatitis C | en_US |
| Subject | Hepatitis D | en_US |
| Subject | prevalence | en_US |
| Subject | Amerindians | en_US |
| Subject | Eastern Amazon | en_US |
| Subject | North Brazil | en_US |
