| Author | Rabelo, Kíssila | |
| Author | Souza, Luiz J. | |
| Author | Salomão, Natália G. | |
| Author | Oliveira, Edson R. A. | |
| Author | Sentinelli, Lynna de Paula | |
| Author | Lacerda, Marcelle S. | |
| Author | Saraquino, Pedro B. | |
| Author | Rosman, Fernando C. | |
| Author | Oliveira, Rodrigo Basílio de | |
| Author | Carvalho, Jorge J. | |
| Author | Paes, Marciano V. | |
| Access date | 2018-10-01T14:53:40Z | |
| Available date | 2018-10-01T14:53:40Z | |
| Document date | 2018 | |
| Citation | RABELO, Kissila; et al. Placental inflammation and fetal injury in a rare Zila case associated with Guillain-Barré Syndrome and abortion. Front. Microbiol., v.9, Article 1018, 10p, May 2018. | pt_BR |
| ISSN | 1664-302X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29198 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Zika virus | pt_BR |
| Subject in Portuguese | Resposta imune | pt_BR |
| Subject in Portuguese | Syndrome de Guillain-Barré | pt_BR |
| Subject in Portuguese | infecção fetal | pt_BR |
| Subject in Portuguese | histopatologia | pt_BR |
| Title | Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barré Syndrome and Abortion | pt_BR |
| Type | Article | |
| DOI | 10.3389/fmicb.2018.01018 | |
| Abstract | Zika virus (ZIKV) is an emerging virus involved in recent outbreaks in Brazil. The association between the virus and Guillain-Barré syndrome (GBS) or congenital disorders has raised a worldwide concern. In this work, we investigated a rare Zika case, which was associated with GBS and spontaneous retained abortion. Using specific anti-ZIKV staining, the virus was identified in placenta (mainly in Hofbauer cells) and in several fetal tissues, such as brain, lungs, kidneys, skin and liver. Histological analyses of the placenta and fetal organs revealed different types of tissue abnormalities, which included inflammation, hemorrhage, edema and necrosis in placenta, as well as tissue disorganization in the fetus. Increased cellularity (Hofbauer cells and TCD8+ lymphocytes), expression of local pro-inflammatory cytokines such as IFN-γ and TNF-α, and other markers, such as RANTES/CCL5 and VEGFR2, supported placental inflammation and dysfunction. The commitment of the maternal-fetal link in association with fetal damage gave rise to a discussion regarding the influence of the maternal immunity toward the fetal development. Findings presented in this work may help understanding the ZIKV immunopathogenesis under the rare contexts of spontaneous abortions in association with GBS. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisiciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Química Orgânica. Laboratório de Modelagem Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Faculdade de Medicina de Campos. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Municipal Jesus. Anatomia Patológica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade do Estado do Rio de Janeiro. Centro Biomédico. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Interdisiciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | immune response | pt_BR |
| Subject | Guillain-Barré syndrome | pt_BR |
| Subject | fetal infection | pt_BR |
| Subject | histopathology | pt_BR |
