| Author | Coelho, Lara | |
| Author | Grinsztejn, Beatriz | |
| Author | Castilho, Jessica L. | |
| Author | De Boni, Raquel B. | |
| Author | Quintana, Marcel S. B. | |
| Author | Campos, Dayse P. | |
| Author | Ribeiro, Sayonara R. | |
| Author | Pacheco, Antonio G. | |
| Author | Veloso, Valdiléa G. | |
| Author | Luz, Paula M. | |
| Access date | 2018-10-04T14:36:34Z | |
| Available date | 2018-10-04T14:36:34Z | |
| Document date | 2016 | |
| Citation | COELHO, Lara et al. Mortality among HIV-Infected Women, Heterosexual Men, and Men Who Have Sex with Men: Insights from an Observational Cohort Study. The lancet HIV, v. 3, n. 10, p. 1-18, 2016. | pt_BR |
| ISSN | 2405-4704 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29338 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Mortality in HIV-infected women, heterosexual men, and men who have sex with men in Rio de Janeiro, Brazil: an observational cohort study | pt_BR |
| Type | Article | |
| DOI | 10.1016/S2352-3018(16)30052-2 | |
| Abstract | Background: Mortality among HIV-infected individuals may differ by sex and mode of HIV acquisition. We studied mortality among women, heterosexual men, and men who have sex with men (MSM) in a cohort from Rio de Janeiro, Brazil. Methods: HIV-infected adults followed at Instituto Nacional de Infectologia Evandro Chagas from 2000–2011 were included. Cox proportional hazards models accounting for competing risks were used to explore risk factors for AIDS and non-AIDS related deaths. Findings—2224 individuals were included (36·7%[817/2224] women, 24·9%[554/2224] heterosexual men, and 38·4% [853/2224] MSM). Throughout the study period, 103 deaths
occurred: 64 due to AIDS-related causes, 31 due to non-AIDS related causes and 8 of unknown causes. In unadjusted analyses, compared to women, hazard of AIDS-related deaths was higher for heterosexual men (hazard ratio [HR] 3·52, 95% confidence interval [95%CI] 1·30–9·08) and for MSM (HR 2·30, 95%CI 0·89–5·94). After adjusting for confounders, excess risk of AIDS-related
death observed for heterosexual men was attenuated (aHR 1·99, 95%CI 0·75–5·25, pvalue=0.163), but unchanged for MSM (aHR 2·24, 95%CI 0·82–6·11, p-value=0.114). Non-AIDS related mortality did not differ by group. Interpretation: Compared to women, increased risk of AIDS-related death among heterosexual men was partially mitigated by risk factors for AIDS mortality while excess risk observed among MSM was unchanged. Further study of reasons for AIDS-related mortality disparity by mode of transmission is needed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Vanderbilt University. School of Medicine. Division of Infectious Diseases. Nashville, TN, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV/AIDS | pt_BR |
| Subject | Antiretroviral therapy | pt_BR |
| Subject | Sex | pt_BR |
| Subject | Mortality | pt_BR |
| Subject | Cohort | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Cox regression models | pt_BR |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
