| Author | Pacheco, P. A. F. | |
| Author | Dantas, L. P. | |
| Author | Ferreira, L. G. B. | |
| Author | Faria, Robson Xavier | |
| Access date | 2018-10-05T18:46:50Z | |
| Available date | 2018-10-05T18:46:50Z | |
| Document date | 2018 | |
| Citation | PACHECO, P. A. F. et al. Purinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets?. Journal of Bioenergetics and Biomembranes, v.50, p.307–313, 2018. | pt_BR |
| ISSN | 0145-479X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29405 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag (Germany) | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Receptores purinérgicos | pt_BR |
| Subject in Portuguese | Doenças negligenciadas | pt_BR |
| Subject in Portuguese | Terapia | pt_BR |
| Subject in Portuguese | ATP | pt_BR |
| Title | Purinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets? | pt_BR |
| Type | Article | |
| DOI | 10.1007/s10863-018-9761-0 | |
| Abstract | Purinergic receptors are widespread in the human organism and are involved in several physiological functions like neurotransmission, nociception, platelet aggregation, etc. In the immune system, they may regulate the expression and release of pro-inflammatory factors as well as the activation and death of several cell types. It is already described the participation of some purinergic receptors in the inflammation and pathological processes, such as a few neglected tropical diseases (NTDs) which affect more than 1 billion people in the world. Although the high social influence those diseases represent endemic countries, most of them do not have an efficient, safe or affordable drug treatment. In that way, this review aims to discuss the current literature involving purinergic receptor and immune response to NTDs pathogens, which may contribute in the search for new therapeutic possibilities. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Virologia Molecular. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e outros Protozoanoses. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Purinergic receptors | pt_BR |
| Subject | ATP | pt_BR |
| Subject | Neglected diseases | pt_BR |
| Subject | Therapy | pt_BR |
| e-ISSN | 573-6881 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
