| Author | Nascimento, Danielle de Oliveira | |
| Author | Vieira de Abreu, Adriana | |
| Author | Arcanjo, Angélica F. | |
| Author | Bozza, Patrícia T. | |
| Author | Zimmerman, Guy A. | |
| Author | Faria Neto, Hugo Caire Castro | |
| Access date | 2018-10-05T18:59:42Z | |
| Available date | 2018-10-05T18:59:42Z | |
| Document date | 2018 | |
| Citation | NASCIMENTO, Danielle de Oliveira et al. Integrin αDβ2 (CD11d/CD18) Modulates Leukocyte Accumulation, Pathogen Clearance, and Pyroptosis in Experimental Salmonella Typhimurium Infection. Frontiers in Immunology, v.9, Article 1128, 11p, May 2018. | pt_BR |
| ISSN | 1664-3224 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29409 | |
| Language | eng | pt_BR |
| Publisher | Frontiers Media | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Salmonella enterica | pt_BR |
| Subject in Portuguese | Piroptose | pt_BR |
| Subject in Portuguese | Salmonella typhimurium | pt_BR |
| Subject in Portuguese | macrófagos | pt_BR |
| Subject in Portuguese | leucócitos mielóides | pt_BR |
| Subject in Portuguese | integrina | pt_BR |
| Title | Integrin αDβ2 (CD11d/CD18) Modulates Leukocyte Accumulation, Pathogen Clearance, and Pyroptosis in Experimental Salmonella Typhimurium Infection | pt_BR |
| Type | Article | |
| Abstract | β2 integrins are critical in host defense responses to invading pathogens and inflammation. Previously, we reported that genetic deficiency of integrin αDβ2 in mice altered outcomes in experimental systemic infections including accelerated mortality in animals infected with Salmonella enterica serovar Typhimurium. Here, we show that deficiency of αDβ2 results in impaired accumulation of leukocytes in response to peritoneal infection by S. Typhimurium, impaired pathogen clearance in vivo, defective bacterial elimination by cultured peritoneal macrophages, and enhanced pyroptosis, a cell death process triggered by Salmonella. Salmonella-infected animals deficient in αDβ2 had increased levels of peritoneal cytokines in addition to other markers of pyroptosis, which may contribute to inflammatory injury and increased mortality in the context of impaired bacterial killing. These observations indicate important contributions of leukocyte integrins to the host response in experimental Salmonella infection and reveal previous activities of αDβ2 in bacterial infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Utah School of Medicine. Department of Internal Medicine. Salt Lake City, UT, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Salmonella enterica serovar | pt_BR |
| Subject | Typhimurium pathogenesis | pt_BR |
| Subject | non-typhoidal Salmonella | pt_BR |
| Subject | myeloid leukocytes | pt_BR |
| Subject | macrophage | pt_BR |
| Subject | integrin | pt_BR |
| Subject | pyroptosis | pt_BR |
| e-ISSN | 10.3389/fimmu.2018.01128 | |
