| Author | Bakal, David R. | |
| Author | Coelho, Lara E. | |
| Author | Luz, Paula Mendes | |
| Author | Clark, Jesse L. | |
| Author | De Boni, Raquel B. | |
| Author | Cardoso, Sandra W. | |
| Author | Veloso,Valdiléa G. | |
| Author | Lake, Jordan E. | |
| Author | Grinsztejn, Beatriz | |
| Access date | 2018-10-08T15:02:09Z | |
| Available date | 2018-10-08T15:02:09Z | |
| Document date | 2018 | |
| Citation | BAKAL, David R. et al. Obesity following ART initiation is common and influenced by both traditional and HIV-/ART-specific risk factors. Journal of Antimicrobial Chemotherapy, v. 73, n. 8, p. 2177-2185, 2018. | pt_BR |
| ISSN | 0305-7453 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29426 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Obesity following ART initiation is common and influenced by both traditional and HIV-/ART-specific risk factors | pt_BR |
| Type | Article | |
| DOI | 10.1093/jac/dky145 | |
| Abstract | Background: Obesity rates are increasing among HIV-infected individuals, but risk factors for obesity development on ART remain unclear. Objectives: In a cohort of HIV-infected adults in Rio de Janeiro, Brazil, we aimed to determine obesity rates before and after ART initiation and to analyse risk factors for obesity on ART. Methods: We retrospectively analysed data from individuals initiating ART between 2000 and 2015. BMI was calculated at baseline (time of ART initiation). Participants who were non-obese at baseline and had 90 days of ART exposure were followed until the development of obesity or the end of follow-up. Obesity incidence rates were estimated using Poisson regression models and risk factors were assessed using Cox regression
models. Results: Of participants analysed at baseline (n " 1794), 61.3% were male, 48.3% were white and 7.9% were obese. Among participants followed longitudinally (n " 1567), 66.2% primarily used an NNRTI, 32.9% a PI and 0.9% an integrase strand transfer inhibitor (INSTI); 18.3% developed obesity and obesity incidence was 37.4 per 1000 person-years. In multivariable analysis, the greatest risk factor for developing obesity was the use of an INSTI as the primary ART core drug (adjusted HR 7.12, P , 0.0001); other risk factors included younger age, female sex, higher baseline BMI, lower baseline CD4! T lymphocyte count, higher baseline HIV-1 RNA, hypertension and diabetes mellitus. Conclusions: Obesity following ART initiation is frequent among HIV-infected adults. Key risk factors include female sex, HIV disease severity and INSTI use. Further research regarding the association between INSTIs and the development of obesity is needed. | pt_BR |
| Affilliation | Department of Medicine. University of California Los Angeles David Geffen School of Medicine. Le Conte Ave. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Department of Medicine. University of California Los Angeles David Geffen School of Medicine. Le Conte Ave. Los Angeles, CA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Department of Medicine. The University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School. Houston, TX, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Obesity | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Body mass index procedure | pt_BR |
| Subject | Follow-up | pt_BR |
| Subject | Integrase inhibitors | pt_BR |
| Subject | HIV infections | pt_BR |
| Embargo date | 2028-08-30 | |
