| Author | Mehrotra, Megha L | |
| Author | Glidden, David V | |
| Author | McMahan, Vanessa | |
| Author | Amico, K Rivet | |
| Author | Hosek, Sybil | |
| Author | Defechereux, Patricia | |
| Author | Mayer, Kenneth H | |
| Author | Veloso,Valdiléa G. | |
| Author | Bekker, Linda-Gail | |
| Author | Avelino-Silva, Vivian I | |
| Author | Schechter, Mauro | |
| Author | Grant, Robert M | |
| Access date | 2018-10-10T16:03:25Z | |
| Available date | 2018-10-10T16:03:25Z | |
| Document date | 2016 | |
| Citation | MEHROTRA, M. L. et al. The Effect of Depressive Symptoms on Adherence to Daily Oral PrEP in Men Who Have Sex with Men and Transgender Women: A Marginal Structural Model Analysis of the iPrEx OLE Study. AIDS and behavior, v. 20, n. 7, p. 1527–1534, 2016 | pt_BR |
| ISSN | 1090-7165 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29492 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | The Effect of Depressive Symptoms on Adherence to Daily Oral PrEP in Men who have Sex with Men and Transgender Women: A Marginal Structural Model Analysis of The iPrEx OLE Study | pt_BR |
| Type | Article | |
| DOI | 10.1007/s10461-016-1415-9 | |
| Abstract | We assessed the role of depressive symptoms on adherence to daily oral FTC/TDF for HIV PrEP in cisgender men who have sex with men (MSM) and transgender women who have sex with men (TGW) using data from the iPrEx OLE study. A marginal structural logistic regression model was used to estimate the effect of time-varying CES-D scores on having protective levels of drug concentration, adjusting for confounding by sexual practices over time, prior adherence, and baseline demographic characteristics. We found a non-monotonic relationship between CES-D score and odds of protective FTC/TDF levels in MSM. We found evidence that the effect of depression on adherence varied between MSM and TGW, and that depressive symptoms did not contribute greatly to decreased adherence on a population scale. We recommend that depressive symptoms not preclude the prescription of PrEP, and that MSM and TGW be studied separately. | pt_BR |
| Affilliation | Grant Lab, J David Gladstone Institutes, GIVI. San Francisco, CA, USA./ University of California. San Francisco, CA, USA. | pt_BR |
| Affilliation | University of California, San Francisco, CA, USA. | pt_BR |
| Affilliation | Grant Lab, J David Gladstone Institutes, GIVI. San Francisco, CA, USA. | pt_BR |
| Affilliation | School of Public Health, University of Michigan, Ann Arbor, MI, USA. | pt_BR |
| Affilliation | Stroger Hospital of Cook County, Chicago, IL, USA. | pt_BR |
| Affilliation | Grant Lab, J David Gladstone Institutes, GIVI. San Francisco, CA, USA. | pt_BR |
| Affilliation | Fenway Community Health, Boston, MA, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Desmond Tutu Health Foundation, Cape Town, South Africa. | pt_BR |
| Affilliation | Universidade de São Paulo. Escola de Medicina. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Escola São Francisco de Assis. Projeto Praça Onze. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | University of California, San Francisco, CA, USA./ Grant Lab, J David Gladstone Institutes, GIVI. San Francisco, CA, USA. | pt_BR |
| Subject | Adherence | pt_BR |
| Subject | Depression | pt_BR |
| Subject | HIV prevention | pt_BR |
| Subject | Marginal structural model | pt_BR |
| Subject | Men who have sex with men | pt_BR |
| Subject | PrEP | pt_BR |
| Subject | Preexposure prophylaxis | pt_BR |
| Subject | Transgender women | pt_BR |
| Subject | iPrEx OLE | pt_BR |
| Embargo date | 2028-08-30 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
