| Author | Cambou, Mary C. | |
| Author | Luz, Paula M. | |
| Author | Lake, Jordan E. | |
| Author | Levi, José Eduardo | |
| Author | Coutinho, José Ricardo | |
| Author | Andrade, Angela de | |
| Author | Heinke, Thais | |
| Author | Derrico, Mônica | |
| Author | Veloso, Valdiléa G. | |
| Author | Friedman, Ruth K. | |
| Author | Grinsztejn, Beatriz | |
| Access date | 2018-10-11T16:11:44Z | |
| Available date | 2018-10-11T16:11:44Z | |
| Document date | 2015 | |
| Citation | CAMBOU, Mary C. et al. Anal Human Papillomavirus (HPV) prevalences and factors associated with abnormal anal cytology in HIV-infected Women in an urban cohort from Rio de Janeiro, Brazil. AIDS Patient Care and STDs, v. 29, n. 1, p. 4–12, 2015 | pt_BR |
| ISSN | 1087-2914 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29535 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Anal human papillomavirus (HPV) prevalences and factors associated with abnormal anal cytology in HIV-infected women in an urban cohort from Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1089/apc.2014.0166 | |
| Abstract | Identifying factors, including human papillomavirus (HPV) genotypes, associated with abnormal anal cytology in HIV-infected women have implications for anal squamous cell cancer (SCC) prevention in HIV-infected women. Anal and cervical samples were collected for cytology, and tested for high-(HR-HPV) and low-risk HPV (LR-HPV) genotypes in a cross-sectional analysis of the IPEC Women's HIV Cohort (Rio de Janeiro, Brazil). Multivariate log-binomial regression models estimated prevalence ratios for factors associated with abnormal anal cytology [≥ atypical squamous cells of undetermined significance, (ASC-US)]. Characteristics of the 863 participants included: median age 42 years, 57% non-white, 79% current CD4+ T-cell count >350 cells/mm(3), 53% HIV-1 viral load <50 copies/mL, median ART duration 5.8 years. Fifty-one percent of anal specimens contained ≥ 1 HR-HPV genotype; 31% had abnormal anal cytology [14% ASC-US, 11% low-grade squamous intra-epithelial lesion, (LSIL); 2% atypical squamous cells-cannot exclude high-grade SIL (ASC-H); 4% high-grade SIL/cancer (HSIL+)]. In multivariate analysis, cervical LSIL+, nadir CD4+ T-cell count ≤ 50 cells/mm(3), HIV-1 viral load ≥ 50 copies/mL, and anal HPV 6, 11, 16, 18, 33, 45, 52, 56, and 58 were associated with ≥ anal ASC-US (p<0.05). Abnormal anal cytology and HR-HPV prevalences were high. HIV-infected women with cervical LSIL+, low nadir CD4+ counts, or detectable HIV-1 viral loads should be a particular focus for enhanced anal SCC screening efforts. | pt_BR |
| Affilliation | David Geffen School of Medicine at UCLA. Division of Infectious Diseases and Program in Global Health. Los Angeles, California, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | David Geffen School of Medicine at UCLA. Division of Infectious Diseases and Program in Global Health. Los Angeles, California, USA. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Salomão Zoppi Diagnósticos. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
