| Author | Lima, Noemia S. | |
| Author | Bonaldo, Myrna C. | |
| Author | Múltipla autoria - ver em Notas | |
| Access date | 2018-10-16T12:22:51Z | |
| Available date | 2018-10-16T12:22:51Z | |
| Document date | 2017 | |
| Citation | MARTINS, Mauricio A. et al. Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque. Aids Research and Human Retroviruses, v.33, n.8, p.843-858, 2017. | pt_BR |
| ISSN | 0889-2229 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29569 | |
| Language | eng | pt_BR |
| Publisher | Mary Ann Liebert | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Depleção Linfocítica | pt_BR |
| Subject in Portuguese | Vacinas contra a SAIDS | pt_BR |
| Subject in Portuguese | primata não humano | pt_BR |
| Subject in Portuguese | HIV/AIDS | pt_BR |
| Title | Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque | pt_BR |
| Type | Article | |
| DOI | 10.1089/aid.2017.0046 | |
| Abstract | Effector memory T cell (TEM) responses display potent antiviral properties and have been linked to stringent
control of simian immunodeficiency virus (SIV) replication. Since recurrent antigen stimulation drives the
differentiation of CD8+ T cells toward the TEM phenotype, in this study we incorporated a persistent herpesviral
vector into a heterologous prime/boost/boost vaccine approach to maximize the induction of TEM responses.
This new regimen resulted in CD8+ TEM-biased responses in four rhesus macaques, three of which controlled
viral replication to <1,000 viral RNA copies/ml of plasma for more than 6 months after infection with SIVmac239.
Over the course of this study, we made a series of interesting observations in one of these successful
controller animals. Indeed, in vivo elimination of CD8ab+ T cells using a new CD8b-depleting antibody did not
abrogate virologic control in this monkey. Only after its CD8a+ lymphocytes were depleted did SIV rebound,
suggesting that CD8aa+ but not CD8ab+ cells were controlling viral replication. By 2 weeks postinfection (PI),
the only SIV sequences that could be detected in this animal harbored a small in-frame deletion in nef affecting
six amino acids. Deep sequencing of the SIVmac239 challenge stock revealed no evidence of this polymorphism.
However, sequencing of the rebound virus following CD8a depletion at week 38.4 PI again revealed
only the six-amino acid deletion in nef. While any role for immunological pressure on the selection of this
deleted variant remains uncertain, our data provide anecdotal evidence that control of SIV replication can be
maintained without an intact CD8ab+ T cell compartment. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Múltipla autoria - ver em Notas. | pt_BR |
| Subject | SIV vaccine | pt_BR |
| Subject | lymphocyte depletion | pt_BR |
| Subject | nonhuman primate | pt_BR |
| Subject | HIV/AIDS | pt_BR |
| DeCS | Vacinas contra a SAIDS | pt_BR |
| DeCS | Depleção Linfocítica | pt_BR |
| e-ISSN | 1931-8405 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
