| Author | Gandhi, Monica | |
| Author | Glidden, David V. | |
| Author | Liu, Albert | |
| Author | Anderson, Peter L. | |
| Author | Horng, Howard | |
| Author | Defechereux, Patricia | |
| Author | Guanira, Juan V. | |
| Author | Grinsztejn, Beatriz | |
| Author | Chariyalertsak, Suwat | |
| Author | Bekker, Linda-Gail | |
| Author | Grant, Robert M. | |
| Access date | 2018-10-18T14:54:49Z | |
| Available date | 2018-10-18T14:54:49Z | |
| Document date | 2015 | |
| Citation | GANDHI, Monica et al. Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: implications for pre-exposure prophylaxis adherence monitoring. The Journal of Infectious Diseases, v. 212, n. 9, p. 1402-1406, Nov. 2015. | pt_BR |
| ISSN | 0022-1899 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29633 | |
| Description | Collaborators: iPrEx Study Team: Javier Lama, Mauro Schechter, Esper G. Kallas, Valdilea Veloso, Kenneth Mayer, Susan Buchbinder, Orlando Montoya, Rivet Amico, Kim Koester, Kathy Mulligan, Martin Casapia, Leslie Z. Benet, Yong Huang, Shirley Yee, Karen Kuncz, Alexander Louie, San Francisco, Ruth Greenblatt, Phyllis Tien, and Bradley Aouizerat. | pt_BR |
| Sponsorship | This work was supported by the Division of Acquired Immunodeficiency Syndrome, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, as a cooperative agreement (UO1 AI84735 to P. L. A., UO1 AI64002, 2R01 AI062333 to R. M. G., and UM1 AI068619). The NIAID also supported the hair assays for this work (R01 AI098472 [principal investigator M. G. with support to H. H.] and U01 AI034989 [San Francisco WIHS, principal investigator Ruth Greenblatt] for hair assay development work). | |
| Language | eng | pt_BR |
| Publisher | Oxford | |
| Rights | open access | pt_BR |
| Title | Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: implications for pre-exposure prophylaxis adherence monitoring | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/infdis/jiv239 | |
| Abstract | Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P < .001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P < .001); hair FTC/DBS TFV-DP (r = 0.74; P < .001); hair FTC/DBS FTC-TP (r = 0.587; P < .001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes. | pt_BR |
| Affilliation | University of California. Department of Medicine. USA. | pt_BR |
| Affilliation | University of California. Department of Epidemiology and Biostatistics. USA. | pt_BR |
| Affilliation | San Francisco Department of Public Health. University of California Bridge HIV. Department of Medicine. USA. | pt_BR |
| Affilliation | University of Colorado. Department of Pharmaceutical Sciences. Denver, USA. | pt_BR |
| Affilliation | University of California. Department of Bioengineering and Therapeutic Sciences. USA. | pt_BR |
| Affilliation | Gladstone Institutes. San Francisco, USA. | pt_BR |
| Affilliation | Investigaciones Medicas en Salud. Lima, Peru. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Chiang Mai University. Research Institute for Health Sciences. Thailand. | pt_BR |
| Affilliation | University of Cape Town. The Desmond Tutu HIV Centre. South Africa. | pt_BR |
| Affilliation | University of California Gladstone Institutes. Department of Medicine. San Francisco, USA. | pt_BR |
| Subject | HIV prevention | pt_BR |
| Subject | PrEP | pt_BR |
| Subject | Adherence | pt_BR |
| Subject | Dried blood spot (DBS) concentrations | pt_BR |
| Subject | Hair concentrations | pt_BR |
| Subject | iPrEx Open Label Extension (OLE) | pt_BR |
| Subject | Pharmacologic monitoring | pt_BR |
| Subject | Pre-exposure prophylaxis | pt_BR |
| Subject | Tenofovir/emtricitabine | pt_BR |
| e-ISSN | 1537-6613 | |
