| Author | Lago, Barbara V. | |
| Author | Mello, Francisco C. A. | |
| Author | Barros, Tairine M. | |
| Author | Mello, Vinicius M. | |
| Author | Villar, Livia M. | |
| Author | Lewis-Ximenez, Lia L. | |
| Author | Pardini, Maria Inês M. C. | |
| Author | Lampe, Elisabeth | |
| Author | on behalf of The Brazilian Hepatitis B Research Group | |
| Access date | 2018-10-25T15:36:19Z | |
| Available date | 2018-10-25T15:36:19Z | |
| Document date | 2018 | |
| Citation | LAGO, Barbara V. et al. Hepatitis D infection in Brazil: Prevalence and geographical distribution of anti-Delta antibody. Journal of Medical Virology, v. 90, p. 1358-1363, Aug. 2018. | pt_BR |
| ISSN | 0146-6615 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29724 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Soroepidemiologia | pt_BR |
| Subject in Portuguese | Vírus da hepatite D | pt_BR |
| Title | Hepatitis D infection in Brazil: Prevalence and geographical distribution of anti-Delta antibody | pt_BR |
| Type | Article | |
| DOI | 10.1002/jmv.25196 | |
| Abstract | In Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti-Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive individuals (55.4% men; mean age 43.1 ± 13.4 years) from 24 of 26 Brazilian states were tested for the presence of anti-Delta antibodies using a commercial immunoassay. Anti-Delta antibodies were detected in 40 samples (3.2%; 52.5% female; mean age of 38.1 ± 13.8 years). Age less than 20 years was significantly associated with anti-HDV positivity (P < 0.001). The distribution of anti-Delta differed markedly in the diverse regions of the country. The highest prevalence of anti-HDV was found in the North (8.5%; P < 0.001), followed by Central West (2.5%), Southeast (1.7%), Northeast (0.8%), and South (0.0%). Anti-Delta antibodies were detected in 12 states, but more than 60%of the positive cases were observed in two states, Amazonas and Acre, located in the western portion of the Amazon region. The overall HDV prevalence of 3.2% emphasizes that HDV is far from being a disease under control in Brazil. Despite the low HDV prevalence in non-endemic regions, this infection persists as a major concern in two states (Acre and Amazonas) in the north of the country, indicating that a continuous epidemiological surveillance program should be implemented in all Brazilian regions. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Estadual Paulista. Laboratório de Biologia Molecular, Faculdade de Medicina. Divisão Homocentro. Campus de Botucatu. Botucatu, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | The Brazilian Hepatitis B Research Group | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | HDV | pt_BR |
| Subject | Seroepidemiology | pt_BR |
| Subject | Hepatitis D virus | pt_BR |
| e-ISSN | 1096-9071 | |
| Embargo date | 2030-31-12 | |
