| Author | Fiscus, Susan A. | |
| Author | Cu-Uvin, Susan | |
| Author | Eshete, Abel Tilahun | |
| Author | Hughes, Michael D. | |
| Author | Bao, Yajing | |
| Author | Hosseinipour, Mina | |
| Author | Grinsztejn, Beatriz | |
| Author | Badal-Faesen, Sharlaa | |
| Author | Dragavon, Joan | |
| Author | Coombs, Robert W. | |
| Author | Braun, Ken | |
| Author | Moran, Laura | |
| Author | Hakim, James | |
| Author | Flanigan, Timothy | |
| Author | Kumarasamy, N. | |
| Author | Campbell, Thomas B. | |
| Access date | 2018-11-05T15:17:14Z | |
| Available date | 2018-11-05T15:17:14Z | |
| Document date | 2013 | |
| Citation | FISCUS, Susan A. et al. Changes in HIV-1 subtypes B and C genital tract RNA in women and men after initiation of antiretroviral therapy. Clinical Infectious Diseases, v. 57, n. 2, p. 290-297, 2013. | pt_BR |
| ISSN | 1058-4838 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29845 | |
| Description | Collaborators: Klingman KL, Nair A, Walawander A, Smeaton LM, De Gruttola V, Martinez AI, Swann E, Barnett RL, Brizz B, Delph Y, Gettinger N, Mitsuyasu RT, Eshleman S, Safren S, Andrade A, Haas DW, Amod F, Berthaud V, Bollinger RC, Bryson Y, Celentano D, Chilongozi D, Cohen M, Collier AC, Currier JS, Eron J, Firnhaber C, Flexner C, Gallant JE, Gulick RM, Hammer SM, Hoffman I, Kazembe P, Kumwenda J, Kumwenda N, Lama JR, Lawrence J, Maponga C, Martinson F, Mayer K, Nielsen K, Pendame RB, Ramratnam B, Rooney JF, Sanchez J, Sanne I, Schooley RT, Snowden W, Solomon S, Tabet S, Taha T, Uy J, van der Horst C, Wanke C, Gormley J, Marcus CJ, Putnam B, Ntshele S, Loeliger E, Pappa KA, Webb N, Shugarts DL, Winters MA, Descallar RS, Sharma J, Poongulali S, Cardoso SW, Faria DL, Berendes S, Burke K, Kanyama C, Kayoyo V, Samaneka WP, Chisada A, Santos B, La Rosa A, Infante R, Balfour HH, Mullan B, Kim GY, Klebert MK, Mildvan D, Revuelta M, Jan Geiseler P, Santos B, Daar ES, Lopez R, Frarey L, Currin D, Haas DH, Bailey VL, Tebas P, Zifchak L, Sha BE, Fritsche JM. | pt_BR |
| Description | A5185s Team | |
| Sponsorship | The project described was supported by the NIAID (award number U01AI068636, AI68634, and AI38858), and by the National Institute of Mental Health and the National Institute of Dental and Craniofacial Research. The pharmaceutical sponsors (Boehringer Ingelheim, Bristol-Myers Squibb, Gilead Sciences, and GlaxoSmithKline) provided study drug, and Gilead Sciences provided funding to purchase study drug that was not otherwise available. Sites were supported by the following grants from the NIAID: AI069424, AI069428, AI027661, AI069495, AI069471, AI046370, AI069423, AI069439, AI69467, AI069463, AI069438, AI069432, AI069436, AI069518, and AI069476-01. Additional funding was provided by the University of Washington Center for AIDS Research, a National Institutes of Health–funded program (P30 AI027757), which is supported by the NIAID, National Cancer Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Child Health and Human Development, National Heart, Lung, and Blood Institute, and National Center for Complementary and Alternative Medicine. | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Changes in HIV-1 Subtypes B and C genital tract RNA in women and men after initiation of antiretroviral therapy | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/cid/cit195 | |
| Abstract | Background: Combination antiretroviral therapy (cART) reduces genital tract human immunodeficiency virus type 1 (HIV-1) load and reduces the risk of sexual transmission, but little is known about the efficacy of cART for decreasing genital tract viral load (GTVL) and differences in sex or HIV-1 subtype. Methods: HIV-1 RNA from blood plasma, seminal plasma, or cervical wicks was quantified at baseline and at weeks 48 and 96 after entry in a randomized clinical trial of 3 cART regimens. Results: One hundred fifty-eight men and 170 women from 7 countries were studied (men: 55% subtype B and 45% subtype C; women: 24% subtype B and 76% subtype C). Despite similar baseline CD4(+) cell counts and blood plasma viral loads, women with subtype C had the highest GTVL (median, 5.1 log10 copies/mL) compared to women with subtype B and men with subtype C or B (4.0, 4.0, and 3.8 log10 copies/mL, respectively; P < .001). The proportion of participants with a GTVL below the lower limit of quantification (LLQ) at week 48 (90%) and week 96 (90%) was increased compared to baseline (16%; P < .001 at both times). Women were significantly less likely to have GTVL below the LLQ compared to men (84% vs 94% at week 48, P = .006; 84% vs 97% at week 96, P = .002), despite a more sensitive assay for seminal plasma than for cervical wicks. No difference in GTVL response across the 3 cART regimens was detected. Conclusions: The female genital tract may serve as a reservoir of persistent HIV-1 replication during cART and affect the use of cART to prevent sexual and perinatal transmission of HIV-1. | pt_BR |
| Affilliation | University of North Carolina. Chapel Hill, NC, USA. | pt_BR |
| Affilliation | Brown University. Providence, RI, USA. | pt_BR |
| Affilliation | Harvard School of Public Health. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard School of Public Health. Boston, MA, USA. | pt_BR |
| Affilliation | Harvard School of Public Health. Boston, MA, USA. | pt_BR |
| Affilliation | UNC Project. Lilongwe, Malawi. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Witwatersrand. Johannesburg, South Africa. | pt_BR |
| Affilliation | University of Washington. Seattle, WA, USA. | pt_BR |
| Affilliation | University of Washington. Seattle, WA, USA. | pt_BR |
| Affilliation | Frontier Science and Research Technology Foundation. Amherst, NY, USA. | pt_BR |
| Affilliation | Social and Scientific Systems. Silver Spring, MD, USA. | pt_BR |
| Affilliation | University of Zimbabwe. Harare, Zimbabwe. | pt_BR |
| Affilliation | Brown University. Providence, RI, USA. | pt_BR |
| Affilliation | YRG Centre for AIDS Research. Chennai, India. | pt_BR |
| Affilliation | University of Colorado. Denver, Aurora, CO, USA. | pt_BR |
| Subject | HIV-1 genital tract RNA | pt_BR |
| Subject | HIV-1 subtypes B and C | pt_BR |
| Subject | Antiretroviral drugs | pt_BR |
