| Author | Joao, Esaú C. | |
| Author | Gouvêa, M. |.|Menezes, J. A. | |
| Author | Sidi, L. C. | |
| Author | Cruz, M. L. S. | |
| Author | Berardo, P. T. | |
| Author | Ceci, L. | |
| Author | Cardoso, C. A. | |
| Author | Teixeira, M. de L. B. | |
| Author | Calvet, G. A. | |
| Author | Matos, H. J. | |
| Access date | 2018-11-12T15:43:18Z | |
| Available date | 2018-11-12T15:43:18Z | |
| Document date | 2012 | |
| Citation | JOÃO, E. C. et al. Factors associated with viral load suppression in HIV-infected pregnant women in Rio de Janeiro, Brazil. International Journal of STD & AIDS, v. 23, n. 1, p. 44–47, 2012. | pt_BR |
| ISSN | 0956-4624 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/29999 | |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Factors associated with viral load suppression in HIV-infected pregnant women in Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1258/ijsa.2011.010545 | |
| Abstract | Viral load (VL) near delivery is a determinant of mother-to-child transmission (MTCT) of HIV. To evaluate factors associated with an undetectable VL near delivery in HIV-infected pregnant women receiving highly active antiretroviral therapy (HAART) and non-HAART regimens, HIV-infected pregnant women with a detectable VL at entry and having used antiretrovirals for ≥4 weeks before delivery were selected. Multivariate analysis was employed using binary logistic unconditional models; the dependent variable was having a VL <400 copies/mL near delivery. VL suppression was achieved in 403/707 women (57%): 65.4% in the HAART group, but only 26% in the non-HAART group P = 0.001. Duration of HAART was correlated with VL suppression, with maximum benefit seen after ≥12 weeks of therapy (odds ratio [OR]: 2.51; 95% confidence interval [CI]: 1.72-3.65). CD4+ cell count near delivery (OR: 1.53; 95% CI: 1.06-2.20) and baseline VL (OR: 0.74; 95% CI: 0.58-0.94) were also independently associated with VL suppression. Overall MTCT rate was 1.6%. HAART for ≥12 weeks, baseline VL and CD4 cell count near delivery were independently associated with viral suppression near delivery. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil./ Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil./ Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | Women | pt_BR |
| Subject | Mother-to-child transmission viral load | pt_BR |
| Subject | Prevention | pt_BR |
| Subject | PMTCT | pt_BR |
| Subject | HAART | pt_BR |
| Subject | Brazil | pt_BR |
| Embargo date | 2028-08-30 | |
| xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |
