| Author | Anderson, Peter L. | |
| Author | Glidden, David V. | |
| Author | Liu, Albert | |
| Author | Buchbinder, Susan | |
| Author | Lama, Javier R. | |
| Author | Guanira, Juan Vicente | |
| Author | McMahan, Vanessa | |
| Author | Bushman, Lane R. | |
| Author | Casapía, Martín | |
| Author | Montoya-Herrera, Orlando | |
| Author | Veloso, Valdiléa G. | |
| Author | Mayer, Kenneth H. | |
| Author | Chariyalertsak, Suwat | |
| Author | Schechter, Mauro | |
| Author | Bekker, Linda-Gail | |
| Author | Kallás, Esper Georges | |
| Author | Grant, Robert M. | |
| Access date | 2018-11-12T17:44:03Z | |
| Available date | 2018-11-12T17:44:03Z | |
| Document date | 2012 | |
| Citation | ANDERSON, Peter L. et al. Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men. Science Translational Medicine, v. 4, n. 151, p. 1-17, Sept. 2012. | pt_BR |
| ISSN | 1946-6234 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30002 | |
| Description | For the iPrEx Study Team. | |
| Sponsorship | NIH R21MH085598 (A.L), UO1 AI084735 (P.L.A.), RO1 AI062333 (R.M.G), and UO1 AI064002 (R.M.G), UL1 RR024131. | |
| Language | eng | pt_BR |
| Rights | open access | pt_BR |
| Title | Emtricitabine-tenofovir exposure and pre-exposure prophylaxis efficacy in men who have sex with men | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1126/scitranslmed.3004006 | |
| Abstract | Drug concentrations associated with protection from HIV-1 acquisition have not been determined. We evaluated drug concentrations among men who have sex with men in a substudy of the iPrEx trial (1). In this randomized placebo-controlled trial, daily oral doses of emtricitabine/tenofovir disoproxil fumarate were used as pre-exposure prophylaxis (PrEP) in men who have sex with men. Drug was detected less frequently in blood plasma and in viable cryopreserved peripheral blood mononuclear cells (PBMCs) in HIV-infected cases at the visit when HIV was first discovered compared with controls at the matched time point of the study (8% versus 44%; P < 0.001) and in the 90 days before that visit (11% versus 51%; P < 0.001). An intracellular concentration of the active form of tenofovir, tenofovir-diphosphate (TFV-DP), of 16 fmol per million PBMCs was associated with a 90% reduction in HIV acquisition relative to the placebo arm. Directly observed dosing in a separate study, the STRAND trial, yielded TFV-DP concentrations that, when analyzed according to the iPrEx model, corresponded to an HIV-1 risk reduction of 76% for two doses per week, 96% for four doses per week, and 99% for seven doses per week. Prophylactic benefits were observed over a range of doses and drug concentrations, suggesting ways to optimize PrEP regimens for this population. | pt_BR |
| Affilliation | University of Colorado. Denver, Aurora, USA. | pt_BR |
| Affilliation | University of California. San Francisco, CA, USA. | pt_BR |
| Affilliation | San Francisco Department of Public Health. HIV Research Section. San Francisco, CA, USA. | pt_BR |
| Affilliation | University of California. San Francisco, CA, USA / San Francisco Department of Public Health. HIV Research Section. San Francisco, CA, USA. | pt_BR |
| Affilliation | Investigaciones Medicas en Salud. Lima, Peru / Asociación Civil Impacta Salud y Educación. Lima, Peru. | pt_BR |
| Affilliation | Asociación Civil Impacta Salud y Educación. Lima, Peru. | pt_BR |
| Affilliation | Gladstone Institute of Virology and Immunology. San Francisco, CA, USA. | pt_BR |
| Affilliation | University of Colorado. Denver, Aurora, USA. | pt_BR |
| Affilliation | Asociación Civil Selva Amazónica. Iquitos, Maynas, Peru. | pt_BR |
| Affilliation | Fundación Ecuatoriana Equidad. Guayaquil, Guayas, Ecuador. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Brown University. Providence, RI, USA / Fenway Health. Fenway Institute. Boston, MA, USA. | pt_BR |
| Affilliation | Chiang Mai University. Research Institute for Health Sciences. Chiang Mai, Thailand. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Escola São Francisco de Assis. Projeto Praça Onze. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Cape Town. Desmond Tutu HIV Centre and Department of Medicine. Cape Town, South Africa. | pt_BR |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Divisão de Imunologia Clínica e Alergia. São Paulo, SP, Brasil / Instituto de Investigação em Imunologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | University of California. San Francisco, CA, USA / Gladstone Institute of Virology and Immunology. San Francisco, CA, USA. | pt_BR |
| Subject | Emtricitabine-tenofovir concentrations | |
| Subject | HIV-1 | |
| Subject | Men who have sex with men | |
| e-ISSN | 1946-6242 | |
