| Author | Carvalho, Karyne Rangel | |
| Author | Carvalho-Assef, Ana Paula D' A. | |
| Author | Santos, Lia Galvão dos | |
| Author | Pereira, Maria José Félix | |
| Author | Asensi, Marise Dutra | |
| Access date | 2018-11-15T15:30:16Z | |
| Available date | 2018-11-15T15:30:16Z | |
| Document date | 2011 | |
| Citation | CARVALHO, Karyne Rangel; et al. Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii. Mem Inst Oswaldo Cruz, v.106, n.4, p.505-506, June 2011. | pt_BR |
| ISSN | 0074-0276 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30045 | |
| Language | eng | pt_BR |
| Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Acinetobacter baumannii - blaOXA-23 | pt_BR |
| Subject in Portuguese | Imipenem | pt_BR |
| Title | Occurrence of blaOXA-23 gene in imipenem-susceptible Acinetobacter baumannii | pt_BR |
| Type | Article | |
| Abstract | The aim of the current study was to describe the occurrence of the blaOXA-23 gene and the ISAba1 element in imipenem-susceptible Acinetobacter baumannii strains. By performing the polymerase chain reaction mapping using combinations of ISAba1 forward primers and the blaOXA-23-like gene reverse primers, we demonstrated that the ISAba1 element did not occur upstream of the blaOXA-23 gene in five of 31 isolates, which explained the lack of resistance to imipenem despite the presence of the blaOXA-23 gene. All of the blaOXA-23-positive isolates were susceptible to imipenem and meropenem with minimal inhibitory concentration ≤ 4 μg/mL. Pulsed-field gel electrophoresis analysis revealed four genotypes among the five blaOXA-23-positive isolates. The current report of the blaOXA-23 gene in imipenem-susceptible isolates provided evidence that this gene may be silently spread in a hospital environment and highlighted the threat of undetected reservoirs of carbapenemase genes. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Federal de Bonsucesso. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Rede Labs D’Or. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | imipenem-susceptible | pt_BR |
| Subject | Acinetobacter baumannii - blaOXA-23 | pt_BR |
| e-ISSN | 1678-8060 | |
