| Author | Freitas, Bethânia Alves de Avelar | |
| Author | Dias, João Victor Leite | |
| Author | Tibães, Gabrielle Guedes | |
| Author | Rocha, Camila Aguiar | |
| Author | Oliveira, Gustavo Henrique Bahia | |
| Author | Grael, Cristiane Fernanda Fuzer | |
| Author | Pires, Herton Helder Rocha | |
| Access date | 2018-11-19T12:21:46Z | |
| Available date | 2018-11-19T12:21:46Z | |
| Document date | 2013 | |
| Citation | FREITAS, Bethânia Alves de Avelar et al. The effect of Ageratum fastigiatum extract on Rhodnius nasutus, vector of Chagas disease. Rev. bras. farmacogn., v. 23, n. 2, p. 366-369, 2013. | pt_BR |
| ISSN | 0102-695X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30087 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Farmacognosia | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Ageratum fastigiatum | pt_BR |
| Subject in Portuguese | atividades inseticidas | pt_BR |
| Subject in Portuguese | triatomineos | pt_BR |
| Title | The effect of Ageratum fastigiatum extract on Rhodnius nasutus, vector of Chagas disease | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1590/S0102-695X2012005000139 | |
| Abstract | Control of Chagas disease is based on insecticide spraying in domiciles in order to exterminate triatomine populations. However, since the vectors differ in susceptibility to currently used insecticides, the screening of the toxic potential of Brazilian flora may identify new molecules lethal to triatomines. This study evaluated the toxicity of ethanolic extract of Ageratum fastigiatum (Gardner) R.M. King & H. Rob., Asteraceae, on Rhodnius nasutus, a known vector of Chagas disease. Ethanolic extracts of the aerial parts of A. fastigiatum were prepared at 25 and 50 mg/mL concentrations, and 5 µL was applied to fifth-instar nymphs of R. nasutus (n=30). Controls included nymphs that were treated with 5 µL ethanol (n=30) or left untreated (n=30). The percentage of dead insects in each group was observed at 24, 48, 72, 96 and 120 h after application. The extracts of A. fastigiatum showed a mortality rate of about 37% and 77% after 120 h, at concentrations of 25 and 50 mg/mL, respectively. In control groups, the mortality rate remained under 7%. The extract of A. fastigiatum contains a coumarin, a molecule with recognized toxicity in insects, and which may be responsible for killing the triatomines. | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Imunologia. Diamantina, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Doenças Parasitárias. Diamantina, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Triatomíneos e Epidemiologia da Doença de Chagas. Belo Horizinte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Doenças Parasitárias. Diamantina, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Doenças Parasitárias. Diamantina, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Doenças Parasitárias. Diamantina, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Fitoquímica. Diamantina, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Doenças Parasitárias. Diamantina, MG, Brazil | pt_BR |
| Subject | Ageratum fastigiatum | pt_BR |
| Subject | insecticidal activity | pt_BR |
| Subject | Triatominae | pt_BR |
