| Author | Nunes, Estevão Portela | |
| Author | Grinsztejn, Beatriz | |
| Author | Schechter, Mauro | |
| Access date | 2018-11-19T15:03:14Z | |
| Available date | 2018-11-19T15:03:14Z | |
| Document date | 2011 | |
| Citation | NUNES, E. P.; Grinsztejn, Beatriz; SCHECHTER, M. The DART Trial: ‘The Doctor’s Dilemma’ revisited. Jounal of Antimicrobial Chemotherapy, v. 66, p. 964-967, 2011. | pt_BR |
| ISSN | 0305-7453 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30103 | |
| Language | por | pt_BR |
| Rights | restricted access | pt_BR |
| Title | The DART trial: 'The doctor's dilemma' revisited | pt_BR |
| Type | Article | |
| DOI | 10.1093/jac/dkr020 | |
| Abstract | Treatment of HIV infection in developing countries, particularly those in Africa, is still a major challenge to healthcare systems with limited laboratory resources. While drug costs have fallen to levels where antiretroviral therapy is now possible in these countries, and results suggest that adherence is as good as in developed countries, questions remain regarding the effect of scarce laboratory resources on treatment monitoring and, hence, outcome. The DART trial aimed to measure the effect of laboratory monitoring. This randomized controlled trial evaluated the differences between routine laboratory monitoring and monitoring driven by clinical events, and was conducted between January 2003 and December 2008 at sites in Uganda and Zimbabwe. The results indicate that clinically driven monitoring is likely to be more cost-effective in this resource-limited situation. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Escola São Francisco de Assis. Projeto Praça Onze. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | HIV | pt_BR |
| Subject | HAART | pt_BR |
| Subject | Resource-limited countries | pt_BR |
| Subject | Cost-effectiveness | pt_BR |
| Embargo date | 2028-08-30 | |
