Author | Gomes, Marisa Zenaide Ribeiro | |
Author | Machado, Carolina Romero | |
Author | Conceição, Magda de Souza da | |
Author | Ortega, Jois Alves | |
Author | Neves, Sonia Maria Ferraz M. | |
Author | Lourenço, Maria Cristina da Silva | |
Author | Asensi, Marise Dutra | |
Access date | 2018-11-26T19:54:31Z | |
Available date | 2018-11-26T19:54:31Z | |
Document date | 2011 | |
Citation | GOMES, Marisa Zenaide Ribeiro et al. Outbreaks, persistence, and high mortality rates of multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions. Brazilian Journal of Infectious Diseases, v. 15, n. 4, p. 312-322, July/Aug. 2011. | pt_BR |
ISSN | 1413-8670 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30212 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Pseudomonas aeruginosa | pt_BR |
Subject in Portuguese | Surtos de doenças | pt_BR |
Subject in Portuguese | Controle de infecção | pt_BR |
Subject in Portuguese | Epidemiologia molecular | pt_BR |
Subject in Portuguese | Síndrome da Imunodeficiência Adquirida | pt_BR |
Title | Outbreaks, persistence, and high mortality rates of multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/s1413-8670(11)70198-2 | pt_BR |
Abstract | Introduction: Authors have reported increased incidence of multiresistant Pseudomonas aeruginosa (MR-PA) infections worldwide over the last decade. Researchers have proposed multifaceted approaches to control MR-PA infections, but none have been reported in the acquired immunodeficiency syndrome (AIDS) setting. Objective and Methods: Herein we report the impact of a multifaceted intervention for controlling MR-PA over five years in a hospital with AIDS-predominant admissions and describe the clinical characteristics of MR-PA infection in our patient population. The clinical outcomes of infected patients and molecular characteristics of the isolated strains were used as tools for controlling MR-PA infection rates. Results: Significant temporary decrease of new infections was achieved after intervention, although a high level of diagnostic suspicion of nosocomial infection was maintained. We obtained 35 P. aeruginosa isolates with multiresistant profiles from 13 infected and 3 colonized patients and 2 environmental samples. Most of the patients (94%) were immunocompromised with AIDS (n = 10) or HTLV-1 infections (n = 5). Of the followed patients, 67% had persistent and/or recurrent infections, and 92% died. We observed differences in the antibiotic-resistance pattern of MR-PA infection/colonization during two outbreaks, although the genetic profiles of the tested strains were identical. Conclusions: Therefore, we concluded that early multidisciplinary interventions are essential for reducing the burden caused by this microorganism in patients with AIDS. Prolonged or suppressive antibiotic-based therapy should be considered for MR-PA infections in patients with AIDS because of the persistence characteristic of MR-PA in these patients. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / University of Texas. MD Anderson Cancer Center. Visiting Scientist. USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Infectologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Infectologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Infectologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Comitê de Controle de Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Bacteriologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Pseudomonas aeruginosa | pt_BR |
Subject | Disease outbreaks | pt_BR |
Subject | Infection control | pt_BR |
Subject | Molecular epidemiology | pt_BR |
Subject | Acquired immunodeficiency syndrome | pt_BR |
e-ISSN | 1678-4391 | |