Author | Thiele, Elizabeth Anne | |
Author | Oliveira, Guilherme Corrêa de | |
Author | Gazzinelli, Andrea | |
Author | Minchella, Dennis J. | |
Access date | 2018-12-07T18:28:05Z | |
Available date | 2018-12-07T18:28:05Z | |
Document date | 2013 | |
Citation | THIELE, Elizabeth Anne et al. Elucidating the temporal and spatial dynamics of Biomphalaria glabrata genetic diversity in three Brazilian villages. Trop Med Int Health., v. 18, n. 10, p. 1164-1173, 2013 | pt_BR |
ISSN | 1360-2276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30429 | |
Language | eng | pt_BR |
Publisher | Blackwell Science Ltd | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Biomphalaria glabrata | pt_BR |
Subject in Portuguese | Esquistossomose mansoni | pt_BR |
Subject in Portuguese | fluxo gênico | pt_BR |
Subject in Portuguese | microsatelite | pt_BR |
Subject in Portuguese | genetica de populaçoes | pt_BR |
Title | Elucidating the temporal and spatial dynamics of Biomphalaria glabrata genetic diversity in three Brazilian villages | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/tmi.12164 | |
Abstract | OBJECTIVE: The freshwater snail Biomphalaria glabrata is the principal intermediate host for the parasite Schistosoma mansoni within Brazil. We assessed the potential effects of snail population dynamics on parasite transmission dynamics via population genetics.
METHODS: We sampled snail populations located within the confines of three schistosome-endemic villages in the state of Minas Gerais, Brazil. Snails were collected from individual microhabitats following seasonal periods of flood and drought over the span of 1 year. Snail spatio-temporal genetic diversity and population differentiation of 598 snails from 12 sites were assessed at seven microsatellite loci.
RESULTS: Average genetic diversity was relatively low, ranging from 4.29 to 9.43 alleles per locus, and overall, subpopulations tended to exhibit heterozygote deficits. Genetic diversity was highly spatially partitioned among subpopulations, while virtually, no partitioning was observed across temporal sampling. Comparison with previously published parasite genetic diversity data indicated that S. mansoni populations are significantly more variable and less subdivided than those of the B. glabrata intermediate hosts.
DISCUSSION: Within individual Brazilian villages, observed distributions of snail genetic diversity indicate temporal stability and very restricted gene flow. This is contrary to observations of schistosome genetic diversity over the same spatial scale, corroborating the expectation that parasite gene flow at the level of individual villages is likely driven by vertebrate host movement. | pt_BR |
Affilliation | Department of Biological Sciences. Purdue University, West Lafayette, IN, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática, Genômica e Grupo de Biologia Computacional. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Department of Biological Sciences. Purdue University, West Lafayette, IN, USA | pt_BR |
Subject | Biomphalaria glabrata | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
Subject | gene flow | pt_BR |
Subject | microsatellite | pt_BR |
Subject | population genetics | pt_BR |
Embargo date | 2100-01-01 | |