| Author | Bozza, Fernando A. | |
| Author | Carnevale, Renata | |
| Author | Japiassú, André Miguel | |
| Author | FariaNeto, Hugo Caire Castro | |
| Author | Angus, Derek C. | |
| Author | Salluh, Jorge I. F. | |
| Access date | 2018-12-09T18:30:15Z | |
| Available date | 2018-12-09T18:30:15Z | |
| Document date | 2010 | |
| Citation | BOZZA, Fernando A. et al. Early fluid resuscitation in sepsis: evidence and perspectives. Shock, v. 34, Supl. 1, p. 40-43, 2010. | pt_BR |
| ISSN | 1073-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30451 | |
| Language | eng | pt_BR |
| Publisher | Lippincott, Williams & Wilkins | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Sepse | pt_BR |
| Subject in Portuguese | Choque | pt_BR |
| Subject in Portuguese | Reposição de fluidos | pt_BR |
| Subject in Portuguese | Campanha Sobrevivendo à Sepse | pt_BR |
| Subject in Portuguese | Otimização hemodinâmica | pt_BR |
| Subject in Portuguese | Terapia direcionada precoce | pt_BR |
| Title | Early fluid resuscitation in sepsis: evidence and perspectives | pt_BR |
| Type | Article | |
| DOI | 10.1097/SHK.0b013e3181e7e668 | |
| Abstract | Hemodynamic instability plays a major role in the pathogenesis of systemic inflammation, tissue hypoxia, and multiple organ dysfunction in sepsis. Aggressive fluid replacement is one of the key interventions for the hemodynamic support in severe sepsis. In this scenario, the ability to restore the imbalance between tissue oxygen demand and supply, the heterogeneity in microcirculation, and endothelial dysfunction in the early stages of sepsis are associated with reduced mortality. In 2001, a single-center randomized controlled trial showed impressive reductions in hospital mortality when patients presenting to the emergency department with severe sepsis were treated with an aggressive protocol of fluids, blood transfusion, and inotropes aiming to improve tissue perfusion. However, external validation of this trial remains to be carried out. To date, there is no unequivocal evidence that such strategy is both universally feasible and effective. In the present article, we review the current evidence and comment on the future perspectives on early fluid resuscitation in severe sepsis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Pittsburgh. Department od Clinical Care Medicine. Pittsburg, Pennsylvania, USA. | pt_BR |
| Affilliation | Instituto Nacional de Câncer. Unidade de Cuidados Intensivos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Sepsis | pt_BR |
| Subject | Surviving Sepsis Campaign | pt_BR |
| Subject | Hemodynamic optimization | pt_BR |
| Subject | Shock | pt_BR |
| Subject | Fluid replacement | pt_BR |
| Subject | Early goaldirected therapy | pt_BR |
| Embargo date | 2030-01-01 | |
