Author | Magalhães, Luisa Mourao Dias | |
Author | Villani, Fernanda Nobre Amaral | |
Author | Nunes, Maria do Carmo Pereira | |
Author | Gollob, Kenneth John | |
Author | Rocha, Manoel Otavio da Costa | |
Author | Dutra, Walderez Ornelas | |
Access date | 2018-12-18T18:38:50Z | |
Available date | 2018-12-18T18:38:50Z | |
Document date | 2013 | |
Citation | MAGALHÃES, Luisa Mourao Dias et al. High interleukin 17 expression is correlated with better cardiac function in human Chagas disease. J Infect Dis., v. 207, n. 4, p. 661-665, 2013 | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30683 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | cardiomiopatia | pt_BR |
Subject in Portuguese | Chagas disease | pt_BR |
Subject in Portuguese | IL-17 | pt_BR |
Subject in Portuguese | imunoregulação | pt_BR |
Subject in Portuguese | patologia | pt_BR |
Subject in Portuguese | T. cruzi | pt_BR |
Subject in Portuguese | Th17 | pt_BR |
Title | High interleukin 17 expression is correlated with better cardiac function in human Chagas disease | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jis724 | |
Abstract | This study was designed to investigate whether the expression of interleukin 17 (IL-17) is associated with the indeterminate or cardiac clinical forms of Chagas disease and whether IL-17 expression can be correlated with patients’ cardiac function. Our results demonstrated that cardiac Chagas patients have a lower intensity of expression of IL-17 by total lymphocytes and lower frequency of circulating T helper 17 cells. Correlative analysis showed that high IL-17 expression was associated with better cardiac function, as determined by left ventricular ejection fraction and left ventricular diastolic diameter values. Therefore, IL-17 expression can be a protective factor to prevent myocardial damage in human Chagas disease. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morphologia. Laboratorio de Interação Celular. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morphologia. Laboratorio de Interação Celular. Belo Horizonte, MG, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Doenças Infecciosas e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Hospital Santa Casa. Belo Horizonte, MG, Brasil/Instituto Nacional de Ciência e Tecnologia e Doenças Tropicais. Belo Horizonte, MG, Brasil/Global Health Program, Center for Infectious Disease Research, SRI International, Menlo Park, California | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Doenças Infecciosas e Medicina Tropical. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biologicas. Departamento de Morphologia. Laboratorio de Interação Celular. Belo Horizonte, MG, Brasil/Instituto Nacional de Ciência e Tecnologia e Doenças Tropicais. Belo Horizonte, MG, Brasil/Global Health Program, Center for Infectious Disease Research, SRI International, Menlo Park, California | pt_BR |
Subject | cardiomyopathy | pt_BR |
Subject | doença de chagas | pt_BR |
Subject | IL-17 | pt_BR |
Subject | immunoregulation | pt_BR |
Subject | pathology; | pt_BR |
Subject | T. cruzi | pt_BR |
Subject | Th17 | pt_BR |
Embargo date | 2020-01-01 | |