| Author | Gusmão, Rafaelle Christine Gomes Fares | |
| Author | Oliveira, Rodrigo Correa de | |
| Author | Araujo, Fernanda Fortes De | |
| Author | Keesen, Tatjana Souza Lima | |
| Author | Chaves, Ana Thereza | |
| Author | Fiuza, Jacqueline Araújo | |
| Author | Ferreira, Karine Silvestre | |
| Author | Rocha, Manoel Otávio da Costa | |
| Author | Gomes, Juliana Assis Silva | |
| Access date | 2018-12-19T11:14:38Z | |
| Available date | 2018-12-19T11:14:38Z | |
| Document date | 2013 | |
| Citation | GUSMÃO, Rafaelle Christine Gomes Fares et al. Identification of phenotypic markers of B cells from patients with Chagas disease. Parasite Immunol., v. 35, n. 7-8, p. 214-23, 2013 | pt_BR |
| ISSN | 0141-9838 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30687 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Linfócitos B | pt_BR |
| Subject in Portuguese | Doença de chagas | pt_BR |
| Subject in Portuguese | IL-10 | pt_BR |
| Subject in Portuguese | imunoregulação | pt_BR |
| Subject in Portuguese | marcadores fenotípicos | pt_BR |
| Title | Identification of phenotypic markers of B cells from patients with Chagas disease. | pt_BR |
| Type | Article | |
| DOI | 10.1111/pim.12038 | |
| Abstract | Chagas disease was discovered more than a hundred years ago, but its pathogenesis is still not completely understood. Autoimmunity is one of the mechanisms shown to contribute to its pathogenesis, which may indicate an important participation of B lymphocytes. Patients with Chagas disease have shown increased percentage of B cells producing IL-10. However, there are no reports of the phenotypic markers of B cells producing IL-10 in patients with Chagas disease. For the first time in the literature, we evaluated the phenotypic profile of distinct markers of B cells from peripheral blood of noninfected individuals and patients with Chagas disease. Our results showed that patients with Chagas disease had a higher expression of CD21 and CD24 on the surface of CD19+ B cells, while CD43 and CD23 were expressed equally in all groups. Moreover, the expression of MHC-II (HLA-DR), CD80, CD86, caspase-3, granzyme B and intracellular IL-10 and TGF-β by CD19+ B cells was higher in patients with Chagas disease. The results of IL-10 production within CD19+ CD5+ CD1d+ B cells showed a higher percentage of this cytokine in patients with Chagas disease. Thus, our data bring a new knowledge about distinct markers of B cells in immune responses of Chagas disease. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal do Rio Grande do Norte. Departamento de Bioquímica. Natal, RN, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | B lymphocytes | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | IL-10 | pt_BR |
| Subject | immunoregulation | pt_BR |
| Subject | phenotypic markers | pt_BR |
| Embargo date | 2100-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
