| Author | Reis, Jordana Grazziela Alves Coelho dos | |
| Author | Passos, Livia | |
| Author | Duarte, Mariana Costa | |
| Author | Araújo, Marcelo Grossi | |
| Author | Azevedo, Ana Carolina Campi | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Magalhães, Vanessa Peruhype | |
| Author | Trindade, Bruno Caetano | |
| Author | Dias, Raquel dos Santos | |
| Author | Martins, Marina Lobato | |
| Author | Proietti, Anna Barbara de Freitas Carneiro | |
| Author | Guedes, Antônio Carlos | |
| Author | Gonçalves, Denise Utsch | |
| Author | Martins Filho, Olindo Assis | |
| Access date | 2018-12-19T12:53:29Z | |
| Available date | 2018-12-19T12:53:29Z | |
| Document date | 2013 | |
| Citation | REIS, Jordana Grazziela Alves Coelho dos et al. Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders. PLoS Negl Trop Dis., v. 7, n. 7, e2328, 2013. | pt_BR |
| ISSN | 1935-2735 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30692 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | HTLV-1 | pt_BR |
| Title | Immunological Profile of HTLV-1-Infected Patients Associated with Infectious or Autoimmune Dermatological Disorders | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0002328 | |
| Abstract | In the present study, the frequency, the activation and the cytokine and chemokine profile of HTLV-1 carriers with or without dermatological lesions were thoroughly described and compared. The results indicated that HTLV-1-infected patients with dermatological lesions have distinct frequency and activation status when compared to asymptomatic carriers. Alterations in the CD4+HLA-DR+, CD8+ T cell, macrophage-like and NKT subsets as well as in the serum chemokines CCL5, CXCL8, CXCL9 and CXCL10 were observed in the HTLV-1-infected group with skin lesions. Additionally, HTLV-1 carriers with dermatological skin lesions showed more frequently high proviral load as compared to asymptomatic carriers. The elevated proviral load in HTLV-1 patients with infectious skin lesions correlated significantly with TNF-α/IL-10 ratio, while the same significant correlation was found for the IL-12/IL-10 ratio and the high proviral load in HTLV-1-infected patients with autoimmune skin lesions. All in all, these results suggest a distinct and unique immunological profile in the peripheral blood of HTLV-1-infected patients with skin disorders, and the different nature of skin lesion observed in these patients may be an outcome of a distinct unbalance of the systemic inflammatory response upon HTLV-1 infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil/Aaron Diamond AIDS Research Center. Rockefeller University. New York, NY, United States of America/HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil/HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. | pt_BR |
| Affilliation | HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazi | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. | pt_BR |
| Affilliation | HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil/HEMOMINAS. Grupo de Pesquisa Interdisciplinar do HTLV – GIPH. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | HTLV-1 | pt_BR |
