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2030-01-01
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- IOC - Artigos de Periódicos [12642]
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THE USE OF LIDOCAINE AS AN ANTI-INFLAMMATORY SUBSTANCE: A SYSTEMATIC REVIEW
Author
Affilliation
Universidade Federal do Rio de Janeiro. Departamento de Odontologia Ortodôntica e Pediátrica. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Departamento de Odontologia Ortodôntica e Pediátrica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Rio de Janeiro. Departamento de Odontologia Ortodôntica e Pediátrica. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Departamento de Odontologia Ortodôntica e Pediátrica. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Departamento de Odontologia Ortodôntica e Pediátrica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Rio de Janeiro. Departamento de Odontologia Ortodôntica e Pediátrica. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Departamento de Odontologia Ortodôntica e Pediátrica. Rio de Janeiro, RJ, Brasil.
Abstract
Objective: To investigate existence of evidence that supports the therapeutical use of
lidocaine as an anti-inflammatory substance.
Methods: A search on health sciences databases was performed, including only papers
published in English until May 2007 which reported in vivo experimental studies that tested
lidocaine as an anti-inflammatory substance and used morphological and/or biochemical
analysis. The keywords used were: ‘‘lidocaine & inflammation’’, ‘‘lidocaine & neutrophils’’
and ‘‘lidocaine & prostaglandin’’. The search results were previous selected by title and
abstract, and then articles were read and those that met inclusion criteria were carefully
analyzed and classified.
Results: Only 10 articles met the inclusion criteria, and were carefully read. They were
ranked (A, B, and C) according to the level of evidence produced. Seven articles were
classified as C, two classified as B, and one classified as A. Despite methodological differences,
all of them, except for one, reported that lidocaine showed anti-inflammatory effects.
Conclusions: According to the reviewed literature, lidocaine has a potential as an antiinflammatory
agent. However, there is still a lack of well-designed studies to support its
clinical use, and none of them evaluated its effects on a mucous epithelium.
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