| Author | Reis, Débora C. | |
| Author | Pinto, Mauro C. X. | |
| Author | Souza-Fagundes, Elaine M. | |
| Author | Rocha, Lucas F. | |
| Author | Pereira, Valéria R. A. | |
| Author | Melo, Cristiane M. L. | |
| Author | Beraldo, Heloisa | |
| Access date | 2018-12-27T14:38:10Z | |
| Available date | 2018-12-27T14:38:10Z | |
| Document date | 2011 | |
| Citation | REIS, Débora C. et al. Investigation on the Pharmacological Profile of Antimony(III) Complexes with Hydroxyquinoline Derivatives: Anti-Trypanosomal Activity and Cytotoxicity against Human Leukemia Cell Lines. BioMetals, v. 24, n. 4, p. 595–601, 1 ago. 2011. | pt_BR |
| ISSN | 1572-8773 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30796 | |
| Sponsorship | CNPq and INCT-INOFAR | pt_BR |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal activity and cytotoxicity against human leukemia cell lines | pt_BR |
| Type | Article | |
| DOI | 10.1007/s10534-011-9407-8 | |
| Abstract | Complexes [Sb(QN)(2)Cl] (1), [Sb(QC)(2)Cl] (2) and [Sb(QI)(2)Cl] (3) were obtained with 8-hydroxyquinoline (HQN), 5-chloro-8-hydroxyquinoline (HQC) and 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, HQI). The quinoline derivatives and their antimony(III) complexes were evaluated for their anti-trypanosomal activity as well as for their cytotoxicity against HL-60 and Jurkat human leukemia cell lines. Upon coordination to antimony(III) the anti-trypanosomal activity of HQC and HQI increases, the highest improvement being observed for complex (3), which was the most active among all studied compounds against both epimastigote and trypomastigote forms of Trypanosoma cruzi. All quinoline derivatives proved to be cytotoxic against both leukemia cell lineages. Upon coordination to antimony(III) the cytotoxicity of HQN improved against Jurkat leukemia cells. While SbCl(3) proved to be cytotoxic against HL-60 cells, it was not active against Jurkat cells. However, its coordination to the quinoline derivatives resulted in complexes with significant cytotoxicity against Jurkat cells. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Fisiologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Fisiologia. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunogenética. Recife, PE, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | 8-Hydroxyquinoline | pt_BR |
| Subject | 5-Chloro-8- hydroxyquinoline | pt_BR |
| Subject | 5-Chloro-7-iodo-8- hydroxyquinoline (clioquinol) | pt_BR |
| Subject | Antimony(III) complexes | pt_BR |
| Subject | Cytotoxicity | pt_BR |
| Subject | Anti-trypanosomal | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Antimônio / Química | pt_BR |
| DeCS | Antineoplásicos / síntese química | pt_BR |
| DeCS | Antineoplásicos / química | pt_BR |
| DeCS | Antineoplásicos / farmacologia | pt_BR |
| DeCS | Agentes Antiprotozoários / síntese química | pt_BR |
| DeCS | Agentes Antiprotozoários / química | pt_BR |
| DeCS | Agentes Antiprotozoários / Farmacologia | pt_BR |
| DeCS | Linha Celular , Tumor | pt_BR |
| DeCS | Proliferação Celular / efeitos de drogas | pt_BR |
| DeCS | Ensaios de Rastreio de Fármacos Antitumorais | pt_BR |
| DeCS | Células HL-60 | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Hidroxiquinolinas / química | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | Ratos, endogâmicos BALB C | pt_BR |
| DeCS | Compostos Organometálicos / síntese química | pt_BR |
| DeCS | Compostos Organometálicos / química | pt_BR |
| DeCS | Compostos Organometálicos / Farmacologia | pt_BR |
| DeCS | Testes de Sensibilidade Parasitária | pt_BR |
| DeCS | Baço / citologia | pt_BR |
| DeCS | Baço / efeitos de drogas | pt_BR |
| DeCS | Relação Estrutura- Atividade | pt_BR |
| DeCS | Trypanosoma cruzi / efeitos de drogas | pt_BR |
| DeCS | Trypanosoma cruzi / crescimento & desenvolvimento | pt_BR |
| Embargo date | 2050-01-01 | |
