Author | Bourguignon, S. C. | |
Author | Faria Neto, Hugo Castro C. | |
Author | Santos, D. O. | |
Author | Alves, C. R. | |
Author | Ferreira, V. F. | |
Author | Gama, I. L. | |
Author | Silva, F. C. | |
Author | Seguins, W. S. | |
Author | Pinho, R. T. | |
Access date | 2018-12-31T13:41:56Z | |
Available date | 2018-12-31T13:41:56Z | |
Document date | 2009 | |
Citation | BOURGUIGNON, S. C. et al. Trypanosoma cruzi: in vitro activity of Epoxy-a-Lap, a derivative of A-lapachone on trypomastigote and amastigote forms. Experimental Parasitology, v.122, p.91-96, Mar. 2009. | pt_BR |
ISSN | 0014-4894 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30812 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Efeito de tripanocida | pt_BR |
Subject in Portuguese | Epoxi-a-Lap | pt_BR |
Subject in Portuguese | a-Lapachone | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Title | Trypanosoma cruzi: in vitro activity of Epoxy-alpha-Lap, a derivative of alpha-lapachone, on trypomastigote and amastigote forms | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.exppara.2009.03.002 | |
Abstract | Chagas disease is an endemic parasitic infection caused by Trypanosomacruzi that affects 18-20 million people in Central and South America. Recently we described the Epoxy-alpha-Lap, an oxyran derivative of alpha-lapachone, which presents a low toxicity profile and a high inhibitory activity against T.cruzi epimastigotes forms, the non-infective form of this parasite. In this work we described the trypanocidal effects of Epoxy-alpha-Lap on extracellular (trypomastigote) and intracellular (amastigote) infective forms of two T. cruzi strains (Y and Colombian) known by their different infective profile. Our results showed that Epoxy-alpha-Lap is lethal to trypomastigote Y and Colombian strains (97% and 84%, respectively). Interestingly, Epoxy-alpha-Lap also showed a trypanocidal effect in human macrophage infected with T. cruzi Y (85.6%) and Colombian (71.9%) strains amastigote forms. Similar effects were observed on T. cruzi amastigote infected Vero cells (96.4% and 95.0%, respectively). Our results pointed Epoxy-alpha-Lap as a potential candidate for Chagas disease chemotherapy since it presents trypanocidal activity on all T. cruzi forms with low) toxicity profile. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Biologia Geral e Celular. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Biologia Geral e Celular. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Biologia Geral e Celular. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | a-Lapachone | pt_BR |
Subject | Epoxi-a-Lap | pt_BR |
Subject | Trypanocidad effect | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Chagas Disease | pt_BR |
Embargo date | 2030-01-01 | |