| Author | Pinto, Antônio Ventura | |
| Author | Castro, Solange Lisboa de | |
| Access date | 2019-01-03T12:23:48Z | |
| Available date | 2019-01-03T12:23:48Z | |
| Document date | 2009 | |
| Citation | PINTO, Antônio Ventura; CASTRO, Solange Lisboa de. The Trypanocidal Activity of Naphthoquinones: A Review. Molecules, v.14, p.4570-4590, 2009. | pt_BR |
| ISSN | 1420-3049 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30848 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Naftoquinonas | pt_BR |
| Subject in Portuguese | Atividade Tripanocida | pt_BR |
| Title | The Trypanocidal Activity of Naphthoquinones: A Review | pt_BR |
| Type | Article | |
| Abstract | Naphthoquinones are compounds present in several families of higher plants.
Their molecular structures confer redox properties, and they are involved in multiple
biological oxidative processes. In folk medicine, especially among Indian populations,
plants containing naphthoquinones have been employed for the treatment of various
diseases. The biological redox cycle of quinones can be initiated by one electron reduction
leading to the formation of semiquinones, unstable intermediates that react rapidly with
molecular oxygen, generating free radicals. Alternatively, the reduction by two electrons,
mediated by DT-diphorase, leads to the formation of hydroquinone. Lapachol, α-lapachone
and β-lapachone, which are isolated from the heartwood of trees of the Bignoniaceae
family, are examples of bioactive naphthoquinones. In this review, we will discuss studies
investigating the activity of these natural products and their derivatives in the context of
the search for alternative drugs for Chagas disease, caused by Trypanosoma cruzi, a
neglected illness that is endemic in Latin America. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Núcleo de Pesquisas em Produtos Naturais. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | naphthoquinones | pt_BR |
| Subject | β-lapachone | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Trypanocidal Activity | pt_BR |
| e-ISSN | 1420-3049 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
