Author | Castro, D. P. | |
Author | Figueiredo, M. B. | |
Author | Genta, F. A. | |
Author | Ribeiro, I. M. | |
Author | Tomassini, T. C. B. | |
Author | Azambuja, P. | |
Author | Garcia, E. S. | |
Access date | 2019-01-08T12:56:58Z | |
Available date | 2019-01-08T12:56:58Z | |
Document date | 2009 | |
Citation | CASTRO, D. P. et al. Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities. Journal of Insect Physiology, v.55, p.532-537, 2009. | pt_BR |
ISSN | 0022-1910 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30914 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Rhodnius prolixus | pt_BR |
Subject in Portuguese | Fagocitose | pt_BR |
Subject in Portuguese | Ácido araquidônico | pt_BR |
Subject in Portuguese | Microagregação | pt_BR |
Subject in Portuguese | Hemócito | pt_BR |
Subject in Portuguese | Fosfolipase a2 | pt_BR |
Subject in Portuguese | Physalis angulata | pt_BR |
Title | Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jinsphys.2009.01.013 | |
Abstract | The effects of physalin B (a natural secosteroidal chemical from Physalis angulata, Solanaceae) on phagocytosis and microaggregation by hemocytes of 5th-instar larvae of Rhodnius prolixus were investigated. In this insect, hemocyte phagocytosis and microaggregation are known to be induced by the platelet-activating factor (PAF) or arachidonic acid (AA) and regulated by phospholipase A(2) (PLA(2)) and PAF-acetyl hydrolase (PAF-AH) activities. Phagocytic activity and formation of hemocyte microaggregates by Rhodnius hemocytes were strongly blocked by oral treatment of this insect with physalin B (1mug/mL of blood meal). The inhibition induced by physalin B was reversed for both phagocytosis and microaggregation by exogenous arachidonic acid (10microg/insect) or PAF (1microg/insect) applied by hemocelic injection. Following treatment with physalin B there were no significant alterations in PLA(2) activities, but a significant enhancement of PAF-AH was observed. These results show that physalin B inhibits hemocytic activity by depressing insect PAF analogous (iPAF) levels in hemolymph and confirm the role of PAF-AH in the cellular immune reactions in R. prolixus. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Entomologia Molecular. CNPq. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos.. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos.. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Entomologia Molecular. CNPq. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Entomologia Molecular. CNPq. Brasil. | pt_BR |
Subject | Rhodnius prolixus | pt_BR |
Subject | Physalis angulata | pt_BR |
Subject | Hemocyte | pt_BR |
Subject | Microaggregation | pt_BR |
Subject | Physalin | pt_BR |
Subject | Phagocytosis | pt_BR |
Subject | Arachidonic acid | pt_BR |
Subject | PAF | pt_BR |
Subject | Phospholipase A2 | pt_BR |
e-ISSN | 1879-1611 | |
Embargo date | 2030-01-01 | |