| Autor | Neiswanger, Katherine | |
| Autor | Walker, K. | |
| Autor | Chirigos, Kevin W. | |
| Autor | Klotz, Cherise M. | |
| Autor | Cooper, Margaret E. | |
| Autor | Bardi, Kathleen M. | |
| Autor | Brandon, Carla A. | |
| Autor | Weinberg, Seth M. | |
| Autor | Vieira, Alexandre R. | |
| Autor | Martin, Rick A. | |
| Autor | Czeizel, Andrew E. | |
| Autor | Castilla, Eduardo E. | |
| Autor | Poletta, Fernando A. | |
| Autor | Marazita, Mary L. | |
| Data de acesso | 2019-01-08T16:24:23Z | |
| Data de disponibilização | 2019-01-08T16:24:23Z | |
| Data do publicação | 2009 | |
| Citação | NEISWANGER, Katherine; et al. Whorl Patterns on the Lower Lip are Associated with Nonsyndromic Cleft Lip with or without Cleft Palate. Am J Med Genet A, v.149 A, n.12, p. 2673–2679, 2009. | pt_BR |
| ISSN | 1552-4825 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30929 | |
| Idioma | eng | pt_BR |
| Direito Autoral | restricted access | |
| Palavras-chave | Padrões Whorl | pt_BR |
| Palavras-chave | Lábio inferior | pt_BR |
| Palavras-chave | Fissura labial não sindrômica | pt_BR |
| Palavras-chave | fenda palatina | pt_BR |
| Título | Whorl patterns on the lower lip are associated with nonsyndromic cleft lip with or without cleft palate | pt_BR |
| Tipo do documento | Article | |
| DOI | 10.1002/ajmg.a.33089 | |
| Resumo em Inglês | Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect due to both genetic and environmental factors. Whorl lip print patterns are circular grooves on the central upper lip and/or the left and right lower lip. To determine if whorls are more common in families with CL/P than in controls, the Pittsburgh Orofacial Cleft Study collected lip prints from over 450 subjects, that is, individuals with CL/P, their relatives, and unrelated controls-from the U.S., Argentina, and Hungary. Using a narrow definition of lower-lip whorl, the frequency of whorls in the U.S. sample was significantly elevated in cleft individuals and their family members, compared to unrelated controls (14.8% and 13.2% vs. 2.3%; P = 0.003 and 0.001, respectively). Whorls were more frequent in CL/P families from Argentina than in CL/P families from the U.S. or Hungary. If these results are confirmed, whorl lip print patterns could be part of an expanded phenotypic spectrum of nonsyndromic CL/P. As such, they may eventually be useful in a clinical setting, allowing recurrence risk calculations to incorporate individual phenotypic information in addition to family history data. | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburgh, USA . | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA. | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA. | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburgh, USA . | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA. | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA. | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburgh, USA . | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburgh, USA / University of Pittsburgh. School of Dental Medicine. Department of Pediatric Dentistry. Pittsburgh, USA. | pt_BR |
| Afiliação | St. Louis University. School of Medicine. Division of Medical Genetics. St. Louis, MO, USA. | pt_BR |
| Afiliação | Genetikai Ártalmak Társadalmi Megelőzése. Budapest, Hungary. | pt_BR |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. ECLAMC (Latin-American Collaborative Study of Congenital Malformations). Rio de Janeiro, RJ, Brasil / CEMIC. Centro de Educación Médica e Investigación Clínica. Buenos Aires, Argentina. | pt_BR |
| Afiliação | CEMIC. Centro de Educación Médica e Investigación Clínica. Buenos Aires, Argentina. | pt_BR |
| Afiliação | University of Pittsburgh. School of Dental Medicine. Center for Craniofacial and Dental Genetics. Pittsburgh, USA / University of Pittsburgh. School of Dental Medicine. Department of Oral Biology. Pittsburgh, USA / University of Pittsburgh. School of Medicine. Clinical and Translational Siciences Institute. Pittsburgh, USA / University of Pittsburgh. School of Medicine. Department of Psychiatry. Pittsburgh, USA. | pt_BR |
| Palavras-chave em inglês | Whorl Patterns | pt_BR |
| Palavras-chave em inglês | Lower Lip | pt_BR |
| Palavras-chave em inglês | Nonsyndromic Cleft Lip | pt_BR |
| Palavras-chave em inglês | Cleft Palate | pt_BR |
| e-ISSN | 1552-4833 | |
| Data de embargo | 2030-01-01 | |
