| Author | Carvalho, Karyne Rangel | |
| Author | Carvalho-Assef, Ana Paula D' A. | |
| Author | Peirano, Gisele | |
| Author | Santos, Lia Cristina Galvão Dos | |
| Author | Pereira, Maria José Felix | |
| Author | Asensi, Marise Dutra | |
| Access date | 2019-01-10T12:29:43Z | |
| Available date | 2019-01-10T12:29:43Z | |
| Document date | 2009 | |
| Citation | CARVALHO, Karyne Rangel et al. Dissemination of multidrug-resistant Acinetobacter baumannii genotypes carrying blaOXA-23 collected from hospitals in Rio de Janeiro, Brazil. International Journal of Antimicrobial Agents, v. 34, p. 25–28, 2009. | pt_BR |
| ISSN | 0924-8579 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/30954 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Resistência a medicamentos | pt_BR |
| Subject in Portuguese | Acinetobacter baumannii | pt_BR |
| Subject in Portuguese | OXA-23 | pt_BR |
| Subject in Portuguese | Tipagem molecular | pt_BR |
| Subject in Portuguese | Rio de Janeiro | pt_BR |
| Title | Dissemination of multidrug-resistant Acinetobacter baumannii genotypes carrying bla(OXA-23) collected from hospitals in Rio de Janeiro, Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.ijantimicag.2008.12.009 | |
| Abstract | The present study reports the dissemination of multidrug-resistant (MDR) OXA-23-producing Acinetobacter baumannii clones throughout hospitals in Rio de Janeiro, Brazil. A total of 110 imipenem-resistant A. baumannii isolates were obtained from January 2006 to September 2007 in eight hospitals. The modified Hodge test was performed to screen for carbapenemase production. Polymerase chain reaction (PCR) and DNA sequencing were performed for the detection of bla(IMP), bla(VIM), bla(OXA-23-like), bla(OXA-24-like), bla(OXA-58) and the class 1 integron. Isolates were typed by pulsed-field gel electrophoresis (PFGE) following digestion with ApaI. All the isolates were MDR and 96 (87.3%) produced the carbapenemase OXA-23. No isolates produced OXA-24, OXA-58 or the metallo-beta-lactamases IMP and VIM. The class 1 integron was absent in all isolates. The A. baumannii isolates were separated into five genotypes, with the highest prevalence of genotype A (71.8%) followed by genotype B (22.7%). Genotype A was present in seven hospitals, whilst genotype B had spread in five hospitals. The OXA-23-producing isolates belonged to all genotypes. The presence of MDR OXA-23-producing A. baumannii in different hospitals in Rio de Janeiro emphasises the need to control the use of carbapenems and to prevent the spread of these organisms in Rio de Janeiro. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Hospital Geral de Bonsucesso. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Multidrug resistance | pt_BR |
| Subject | Acinetobacter baumannii | pt_BR |
| Subject | OXA-23 | pt_BR |
| Subject | Molecular typing | pt_BR |
| Subject | Rio de Janeiro | pt_BR |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
