| Author | Rizzo, Juliana | |
| Author | Colombo, Ana C. | |
| Author | Zamith-Miranda, Daniel | |
| Author | Silva, Vanessa K. A. | |
| Author | Allegood, Jeremy C. | |
| Author | Casadevall, Arturo | |
| Author | Del Poeta, Maurizio | |
| Author | Nosanchuk, Joshua D. | |
| Author | Kronstad, James W. | |
| Author | Rodrigues, Marcio Lourenço | |
| Access date | 2019-01-11T23:17:48Z | |
| Available date | 2019-01-11T23:17:48Z | |
| Document date | 2018 | |
| Citation | RIZZO, J. et al. The putative fl ippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans. BBA - Molecular Cell Research, v. 1865, p. 532-541, 2018. | pt_BR |
| ISSN | 0167-4889 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31007 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Title | The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.bbamcr.2017.12.007 | |
| Abstract | Flippases are responsible for the asymmetric distribution of phospholipids in biological membranes. In the encapsulated fungal pathogen Cryptococcus neoformans, the putative flippase Apt1 is an important regulator of polysaccharide secretion and pathogenesis in mice by unknown mechanisms. In this study, we analyzed the role of C. neoformans Apt1 in intracellular membrane architecture and synthesis of polysaccharide and lipids. Analysis of wild type (WT), apt1Δ (mutant) and apt1Δ | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Stony Brook University. Departments of Biochemistry and Molecular Genetics and Microbiology. New York, USA / Universidade Federal do Rio de Janeiro. Programa de Pós-Graduação em Química Biológica do Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brazil. | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Departments of Medicine and Microbiology and Immunology. New York, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Programa de Pós-Graduação em Biologia Parasitária. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Virginia Commonwealth University School of Medicine. Department of Biochemistry and Molecular Biology. Richmond, USA. | pt_BR |
| Affilliation | Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology. Baltimore, USA. | pt_BR |
| Affilliation | Stony Brook University. Departments of Biochemistry and Molecular Genetics and Microbiology. Division of Infectious Diseases. New York, USA / Veterans Administration Medical Center. Northport, USA. | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Departments of Medicine and Microbiology and Immunology. New York, USA. | pt_BR |
| Affilliation | The University of British Columbia. Faculty of Land and Food Systems. Department of Microbiology and Immunology. Michael Smith Laboratories. Vancouver, Canada | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cryptococcus neoformans | pt_BR |
| Subject | Flippases | pt_BR |
| Subject | Vacuole | pt_BR |
| Subject | Polysaccharide secretion | pt_BR |
| Subject | Lipid biosynthesis | pt_BR |
| Embargo date | 2022-01-01 | |
