Author | Lana, Marta de | |
Author | Lopes, Leonardo A. | |
Author | Martins, Helen R. | |
Author | Bahia, Maria T. | |
Author | Assis, Girley F. Machado de | |
Author | Wendling, Ana P. | |
Author | Martins Filho, Olindo A. | |
Author | Montoya, Roberto A. | |
Author | Dias, João C. P. | |
Author | Albajar-Viñas, Pedro | |
Author | Coura, José Rodrigues | |
Access date | 2019-01-15T12:18:19Z | |
Available date | 2019-01-15T12:18:19Z | |
Document date | 2009 | |
Citation | LANA, Marta de et al. Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 8, p. 1139-1147, Dec. 2009. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31035 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
Rights | open access | |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | Evolução Clínica | pt_BR |
Subject in Portuguese | tratamento etiológico | pt_BR |
Subject in Portuguese | avaliação clínico-laboratorial | pt_BR |
Subject in Portuguese | benzonidazol | pt_BR |
Title | Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment | pt_BR |
Type | Article | pt_BR |
Abstract | Twenty-eight Chagas disease patients (CD), 22 with the indeterminate clinical form (IND) and six with the cardiac or digestive form (CARD/DIG), were treated with benznidazole and underwent clinical and laboratorial analysis before (IND and CARD/DIG) and nine years after [patients after treatment (CDt), patients with the indeterminate clinical form at treatment onset (INDt) and with the cardiac or digestive form at treatment onset (CARD/DIGt)] treatment. The data demonstrate that 82.1% of CDt patients (23/28) remained clinically stable and 95.4% of the INDt (21/22) and 33.3% of the CARD/DIGt (2/6) patients showed unaltered physical and laboratorial examinations. The clinical evolution rate was 2%/year and was especially low in INDt patients (0.5%/year) relative to CARD/DIGt patients (7.4%/year). Positive haemoculture in treated patients was observed in 7.1% of the cases. None of the INDt (0/21) and 33.3% of the CARD/DIGt (2/6) patients displayed positive cultures. The PCR presented a positive rate significantly higher (85.2%, 23/27) than haemoculture and two samples from the same patient revealed the same result 57.7% of the patients. Conventional serology-ELISA on 16 paired samples remained positive in all individuals. Semi-quantitative ELISA highlighted significant decreases in reactivity, particularly in INDt relative to IND. Non-conventional serology-FC-ALTA-IgG, after treatment, showed positive results in all sera and 22 paired samples examined at seven and nine years after treatment, demonstrated significantly lower reactivity, particularly in INDt patients. This study was retrospective in nature, had a low number of samples and lacked an intrinsic control group, but the data corroborate other results found in the literature. The data also demonstrate that, even though a cure has not been detected in the none-treated patients, the benefits for clinical evolution were selectively observed in the group of INDt patients and did not occur for CARD/DIGt patients. | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Outro Preto, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Organização Pan-Americana da Saúde. Brasília, DF, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Chagas Disease | pt_BR |
Subject | Aetiological treatment | pt_BR |
Subject | Benznidazole | pt_BR |
Subject | Clinical-laboratorial evaluation | pt_BR |
Subject | Clinical evolution | pt_BR |
e-ISSN | 1678-8060 | |
xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |