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AutorLana, Marta de
AutorLopes, Leonardo A.
AutorMartins, Helen R.
AutorBahia, Maria T.
AutorAssis, Girley F. Machado de
AutorWendling, Ana P.
AutorMartins Filho, Olindo A.
AutorMontoya, Roberto A.
AutorDias, João C. P.
AutorAlbajar-Viñas, Pedro
AutorCoura, José Rodrigues
Fecha de acceso2019-01-15T12:18:19Z
Fecha de disponibilización2019-01-15T12:18:19Z
Fecha de publicación2009
ReferenciaLANA, Marta de et al. Clinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatment. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 104, n. 8, p. 1139-1147, Dec. 2009.pt_BR
ISSN0074-0276pt_BR
URIhttps://www.arca.fiocruz.br/handle/icict/31035
Idiomaengpt_BR
EditorFundação Oswaldo Cruz. Instituto Oswaldo Cruzpt_BR
Derechos de autoropen access
Palabras clave en PortuguésDoença de Chagaspt_BR
Palabras clave en PortuguésEvolução Clínicapt_BR
Palabras clave en Portuguéstratamento etiológicopt_BR
Palabras clave en Portuguésavaliação clínico-laboratorialpt_BR
Palabras clave en Portuguésbenzonidazolpt_BR
TítuloClinical and laboratory status of patients with chronic Chagas disease living in a vector-controlled area in Minas Gerais, Brazil, before and nine years after aetiological treatmentpt_BR
Tipo del documentoArticle
Resumen en InglésTwenty-eight Chagas disease patients (CD), 22 with the indeterminate clinical form (IND) and six with the cardiac or digestive form (CARD/DIG), were treated with benznidazole and underwent clinical and laboratorial analysis before (IND and CARD/DIG) and nine years after [patients after treatment (CDt), patients with the indeterminate clinical form at treatment onset (INDt) and with the cardiac or digestive form at treatment onset (CARD/DIGt)] treatment. The data demonstrate that 82.1% of CDt patients (23/28) remained clinically stable and 95.4% of the INDt (21/22) and 33.3% of the CARD/DIGt (2/6) patients showed unaltered physical and laboratorial examinations. The clinical evolution rate was 2%/year and was especially low in INDt patients (0.5%/year) relative to CARD/DIGt patients (7.4%/year). Positive haemoculture in treated patients was observed in 7.1% of the cases. None of the INDt (0/21) and 33.3% of the CARD/DIGt (2/6) patients displayed positive cultures. The PCR presented a positive rate significantly higher (85.2%, 23/27) than haemoculture and two samples from the same patient revealed the same result 57.7% of the patients. Conventional serology-ELISA on 16 paired samples remained positive in all individuals. Semi-quantitative ELISA highlighted significant decreases in reactivity, particularly in INDt relative to IND. Non-conventional serology-FC-ALTA-IgG, after treatment, showed positive results in all sera and 22 paired samples examined at seven and nine years after treatment, demonstrated significantly lower reactivity, particularly in INDt patients. This study was retrospective in nature, had a low number of samples and lacked an intrinsic control group, but the data corroborate other results found in the literature. The data also demonstrate that, even though a cure has not been detected in the none-treated patients, the benefits for clinical evolution were selectively observed in the group of INDt patients and did not occur for CARD/DIGt patients.pt_BR
AfiliaciónUniversidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brasil.pt_BR
AfiliaciónUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil.pt_BR
AfiliaciónUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil.pt_BR
AfiliaciónUniversidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Ciências Biológicas. Outro Preto, MG, Brasil.pt_BR
AfiliaciónUniversidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Ouro Preto, MG, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.pt_BR
AfiliaciónOrganização Pan-Americana da Saúde. Brasília, DF, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil.pt_BR
AfiliaciónFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil.pt_BR
Palavras clave en InglêsChagas Diseasept_BR
Palavras clave en InglêsAetiological treatmentpt_BR
Palavras clave en InglêsBenznidazolept_BR
Palavras clave en InglêsClinical-laboratorial evaluationpt_BR
Palavras clave en InglêsClinical evolutionpt_BR
e-ISSN1678-8060
xmlui.metadata.dc.subject.ods03 Saúde e Bem-Estar


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