| Author | Antunes, Mariana A. | |
| Author | Abreu, Soraia C. | |
| Author | Rodrigues, Nilsa R. Damaceno | |
| Author | Parra, Edwin R. | |
| Author | Capelozzi, Vera L. | |
| Author | Pinart, Mariona | |
| Author | Romero, Pablo V. | |
| Author | Silva, Patrícia M. R. | |
| Author | Martins, Marco Aurélio | |
| Author | Rocco, Patricia R. M. | |
| Access date | 2019-01-17T11:26:20Z | |
| Available date | 2019-01-17T11:26:20Z | |
| Document date | 2009 | |
| Citation | ANTUNES, Mariana A. et al. Different strains of mice present distinct lung tissue mechanics and extracellular matrix composition in a model of chronic allergic asthma. Respiratory Physiology & Neurobiology, v.165, p.202–207, 2009. | pt_BR |
| ISSN | 1569-9048 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31093 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Mecânica dos tecidos | pt_BR |
| Subject in Portuguese | Asma | pt_BR |
| Subject in Portuguese | Parênquima pulmonar | pt_BR |
| Subject in Portuguese | Colágeno e fibras elásticas | pt_BR |
| Subject in Portuguese | Actina | pt_BR |
| Title | Different strains of mice present distinct lung tissue mechanics and extracellular matrix composition in a model of chronic allergic asthma | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.resp.2008.12.003 | |
| Abstract | The impact of genetic factors on asthma is well recognized but poorly understood. We tested the hypothesis that different mouse strains present different lung tissue strip mechanics in a model of chronic allergic asthma and that these mechanical differences may be potentially related to changes of extracellular matrix composition and/or contractile elements in lung parenchyma. Oscillatory mechanics were analysed before and after acetylcholine (ACh) in C57BL/10, BALB/c, and A/J mice, subjected or not to ovalbumin sensitization and challenge. In controls, tissue elastance (E) and resistance (R), collagen and elastic fibres' content, and alpha-actin were higher in A/J compared to BALB/c mice, which, in turn, were more elevated than in C57BL/10. A similar response pattern was observed in ovalbumin-challenged animals irrespective of mouse strain. E and R augmented more in ovalbumin-challenged A/J [E: 22%, R: 18%] than C57BL/10 mice [E: 9.4%, R: 11%] after ACh In conclusion, lung parenchyma remodelled differently yielding distinct in vitro mechanics according to mouse strain. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Departamento de Patologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Departamento de Patologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Departamento de Patologia. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | IDIBELL L’Hospitalet. Laboratory of Experimental Pneumology. Barcelona, Spain. | pt_BR |
| Affilliation | IDIBELL L’Hospitalet. Laboratory of Experimental Pneumology. Barcelona, Spain. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Tissue mechanics | pt_BR |
| Subject | Asthma | pt_BR |
| Subject | Lung parenchyma | pt_BR |
| Subject | Collagen and elastic fibres | pt_BR |
| Subject | Actin | pt_BR |
| e-ISSN | 1878-1519 | |
| Embargo date | 2030-01-01 | |
