| Author | Charret, Karen S. | |
| Author | Rodrigues, Raquel F. | |
| Author | Bernardino, Alice M. R. | |
| Author | Gomes, Adriana O. | |
| Author | Carvalho, Adriana V. | |
| Author | Canto-Cavalheiro, Marilene M. | |
| Author | Leon, Leonor L. | |
| Author | Amaral, Veronica F. | |
| Access date | 2019-01-17T12:14:15Z | |
| Available date | 2019-01-17T12:14:15Z | |
| Document date | 2009 | |
| Citation | CHARRET, Karen S. et al. Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis. Am. J. Trop. Med. Hyg., v.80, n.4, p.568-573, 2009. | pt_BR |
| ISSN | 0002-9637 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31098 | |
| Language | eng | pt_BR |
| Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Subject in Portuguese | tratamento oral | pt_BR |
| Subject in Portuguese | Infecção murina | pt_BR |
| Subject in Portuguese | Derivados de pirazoleto-carbohydrazide | pt_BR |
| Title | Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis | pt_BR |
| Type | Article | |
| Abstract | Newly synthesized pyrazole carbohydrazide derivatives with substituents X = Br/Y = NO 2 and X =
NO 2 /Y = Cl were independently investigated in the CBA mouse model of cutaneous leishmaniasis. Animals
were infected with Leishmania amazonensis and treated two weeks after the parasitic infection with the pyrazole carbohydrazides
for 45 days. Oral treatment with both compounds controlled evolution of footpad cutaneous lesions and
dissemination of parasites to draining lymph nodes. Nitric oxide generation was observed in supernatants of lymph node
cells from infected CBA mice that were treated with these compounds. The pyrazole carbohydrazide derivatives did not
show any toxicity or cause alterations in body weight, plasma concentrations of alanine aminotransferase and aspartate
aminotransferase, and urinary creatinine levels, but promoted a small decrease in blood neutrophils. These results
provide new perspectives on the development of drugs with activities against leishmaniasis. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Programa de Pós-graduação em Química Orgânica.Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Programa de Pós-graduação em Química Orgânica. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunobiologia. Niterói, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunobiologia. Niterói, RJ, Brasil. | pt_BR |
| Subject | Oral treatment | pt_BR |
| Subject | Pyrazole Carbohydrazide Derivatives | pt_BR |
| Subject | Murine infection | pt_BR |
| Subject | Leishmania amazonensis | pt_BR |
| e-ISSN | 1476-1645 | |
