| Author | Silva, Patrícia M. R. e | |
| Author | Carvalho, Vinicius F. | |
| Author | Cordeiro, Renato S. B. | |
| Author | Martins, Marco A. | |
| Access date | 2019-01-17T15:30:35Z | |
| Available date | 2019-01-17T15:30:35Z | |
| Document date | 2009 | |
| Citation | SILVA, Patrícia M. R. e; et al. Down-Regulation of Allergic Responses in Conditions of Experimental Diabetes: A Role for Glucocorticoids?. Neuroimmunomodulation, v. 16, p. 13-18, 2009. | pt_BR |
| ISSN | 1021-7401 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31119 | |
| Language | eng | pt_BR |
| Publisher | Karger Publishers | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Diabetes | pt_BR |
| Subject in Portuguese | Eixo hipotálamo-hipófise-adrenocortical | pt_BR |
| Subject in Portuguese | atopia | pt_BR |
| Subject in Portuguese | Mastócitos | pt_BR |
| Subject in Portuguese | Glucocorticóides | pt_BR |
| Title | Down-regulation of allergic responses in conditions of experimental diabetes: a role for glucocorticoids? | pt_BR |
| Type | Article | |
| DOI | 10.1159/000179662 | |
| Abstract | The prevalence of atopic diseases and diabetes is increasing worldwide, though the co-occurrence of both diseases in the same individual is less frequent than predicted. Previously published studies suggest that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 diabetes. However, down-regulation of the IgE-mast cell system can also markedly contribute to the lack of responsiveness to local and systemic allergen challenges in diabetic conditions. Moreover, dysregulation of the hypothalamic-pituitary-adrenocortical axis and elevated endogenous glucocorticoid levels play a pertinent role in some of the pathological-related processes associated with poorly controlled or uncontrolled diabetes. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Atopy | pt_BR |
| Subject | Diabetes | pt_BR |
| Subject | Glucocorticoids | pt_BR |
| Subject | Mast cells | pt_BR |
| Subject | Hypothalamic-pituitary-adrenocortical axis | pt_BR |
| e-ISSN | 1423-0216 | |
| Embargo date | 2030-01-01 | |
