| Author | Freitas, Isabel Ferreira LaRocque de | |
| Author | Rocha, Juliana Dutra B. | |
| Author | Nunes, Marise Pinheiro | |
| Author | Oliveira, Priscila Angelica V. | |
| Author | Nascimento, Danielle de Oliveira | |
| Author | Lima, Leonardo Freire de | |
| Author | Takiya, Christina Maeda | |
| Author | Morrot, Alexandre | |
| Author | Ricardo, Debora Decote | |
| Author | Previato, Jose Osvaldo | |
| Author | Previato, Lucia Mendonça | |
| Author | Lima, Celio Geraldo Freire de | |
| Access date | 2019-01-22T15:42:06Z | |
| Available date | 2019-01-22T15:42:06Z | |
| Document date | 2018 | |
| Citation | FREITAS, Isabel Fereira LaRocque de; et al. Involvement of the capsular GalXMinduced IL-17 cytokine in the control of Cryptococcus neoformans infection. Scientific Reports, v.8, 16378, 16p, Nov. 2018. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31228 | |
| Language | eng | pt_BR |
| Publisher | Nature Research | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Cryptococcus neoformans | pt_BR |
| Subject in Portuguese | citocina IL-17 capsulada | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | GalXMinduced | pt_BR |
| Subject in Portuguese | Controle | pt_BR |
| Title | Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection | pt_BR |
| Type | Article | |
| DOI | 10.1038/s41598-018-34649-4 | |
| Abstract | Cryptococcus neoformans is an opportunistic fungus that can cause lethal brain infections in immunosuppressed individuals. Infection usually occurs via the inhalation of a spore or desiccated yeast which can then disseminate from the lung to the brain and other tissues. Dissemination and disease is largely influence by the production of copious amounts of cryptococcal polysaccharides, both which are secreted to the extracellular environment or assembled into a thick capsule surrounding the cell body. There are two important polysaccharides: glucuronoxylomannan (GXM) and galactoxylomannan, also called as glucuronoxylomanogalactan (GXMGal or GalXM). Although GXM is more abundant, GalXM has a more potent modulatory effect. In the present study, we show that GalXM is a potent activator of murine dendritic cells, and when co-cultured with T cells, induces a Th17 cytokine response. We also demonstrated that treating mice with GalXM prior to infection with C. neoformans protects from infection, and this phenomenon is dependent on IL-6 and IL-17. These findings help us understand the immune biology of capsular polysaccharides in fungal pathogenesis. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Seropédica, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Cryptococcus neoformans | pt_BR |
| Subject | Infection | pt_BR |
| Subject | IL-17 cytokine | pt_BR |
| Subject | Controle | pt_BR |
| Subject | capsular GalXMinduced | pt_BR |
