| Author | Larocca, Ticiana Ferreira | |
| Author | Souza, Bruno Solano de Freitas | |
| Author | Macêdo, Carolina Thé | |
| Author | Azevedo, Carine Machado | |
| Author | Vasconcelos, Juliana Fraga | |
| Author | Silva, Daniela Nascimento | |
| Author | Portella, Diogo Crispim Nascimento | |
| Author | dosSantos, Washington Luis Conrado | |
| Author | Tavora, Fabio Rocha Fernandes | |
| Author | Souza Neto, João David de | |
| Author | Santos, Ricardo Ribeiro dos | |
| Author | Soares, Milena Botelho Pereira | |
| Access date | 2019-01-25T17:58:58Z | |
| Available date | 2019-01-25T17:58:58Z | |
| Document date | 2018 | |
| Citation | LAROCCA, T. F. et al. Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy. Surgical and Experimental Pathology, 2018. | pt_BR |
| ISSN | 2520-8454 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31313 | |
| Sponsorship | National Council for Research (CNPq), Research Foundation of Bahia State (FAPESB), and Funding
Authority for Studies and Projects (FINEP). | pt_BR |
| Language | eng | pt_BR |
| Publisher | BMC | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Síndecan-4 | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Cardiomiopatia | pt_BR |
| Title | Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy | pt_BR |
| Type | Article | pt_BR |
| Abstract | Chronic Chagas cardiomyopathy (CCC) is characterized by the presence of a multifocal inflammatory
response and myocardial damage, leading to fibrosis, arrhythmias and ventricular dysfunction. The expression of
syndecan-4, a transmembrane proteoglycan, was previously found to be increased in the hearts of mice chronically
infected with Trypanosoma cruzi. The possible involvement of syndecan-4 in the disease pathogenesis, however,
remains unknown. Here we evaluated the pattern of expression of syndecan-4 in the heart tissue of T. cruzi infected
mice and subjects with Chagas cardiomyopathy, correlating with the degree of inflammation and fibrosis. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Messejana Hospital. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Messejana Hospital. Fortaleza, CE, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| Subject | Syndecan-4 | pt_BR |
| Subject | Chagas disease | pt_BR |
| Subject | Cardiomyopathy | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
