| Author | Souza, Thiara Manuele Alves de Souza | |
| Author | Nogueira, Fernanda de Bruycker | |
| Author | Carneiro, Thaís Chouin | |
| Author | Faria, Nieli Rodrigues da Costa | |
| Author | Nunes, Priscila Conrado Guerra | |
| Author | Heringer, Manoela | |
| Author | Lima, Monique da Rocha Queiroz | |
| Author | Corrêa, Jéssica Badolato | |
| Author | Cipitelli, Márcio da Costa | |
| Author | Azereedo, Elzinandes Leal de | |
| Author | Nogueira, Rita Maria Ribeiro | |
| Author | Santos, Flávia Barreto dos | |
| Author | Ribeiro, Edcelha D`Athaide | |
| Author | Corrêa, Valmir Corrêa e | |
| Author | Damasco, Paulo Vieira | |
| Author | Santos, Carla Cunha | |
| Access date | 2019-01-31T15:32:23Z | |
| Available date | 2019-01-31T15:32:23Z | |
| Document date | 2018 | |
| Citation | SOUZA, Thiara Manuele Alves de; et al. Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016. Viruses, v.10, n.623, 17p, 2018. | pt_BR |
| ISSN | 1999-4915 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31362 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Chikungunya vírus | pt_BR |
| Subject in Portuguese | Coinfecção | pt_BR |
| Subject in Portuguese | Vigilância | pt_BR |
| Subject in Portuguese | Genótipo asiático | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Title | Following in the Footsteps of the Chikungunya Virus in Brazil: The First Autochthonous Cases in Amapá in 2014 and Its Emergence in Rio de Janeiro during 2016 | pt_BR |
| Type | Article | |
| DOI | 10.3390/v10110623 | |
| Abstract | Currently, Brazil lives a triple arboviruses epidemic (DENV, ZIKV and CHIKV) making the
differential diagnosis difficult for health professionals. Here, we aimed to investigate chikungunya
cases and the possible occurrence of co-infections during the epidemic in Amapá (AP) that started in
2014 when the first autochthonous cases were reported and in Rio de Janeiro (RJ) in 2016. We further
performed molecular characterization and genotyping of representative strains. In AP, 51.4% of
the suspected cases were confirmed for CHIKV, 71.0% (76/107). Of those, 24 co-infections by
CHIKV/DENV, two by CHIKV/DENV-1, and two by CHIKV/DENV-4 were observed. In RJ,
76.9% of the suspected cases were confirmed for CHIKV and co-infections by CHIKV/DENV (n = 8)
and by CHIKV/ZIKV (n = 17) were observed. Overall, fever, arthralgia, myalgia, prostration,
edema, exanthema, conjunctival hyperemia, lower back pain, dizziness, nausea, retroorbital pain,
and anorexia were the predominating chikungunya clinical symptoms described. All strains analyzed
from AP belonged to the Asian genotype and no amino acid changes were observed. In RJ,
the East-Central-South-African genotype (ECSA) circulation was demonstrated and no E1-A226V
mutation was observed. Despite this, an E1-V156A substitution was characterized in two samples
and for the first time, the E1-K211T mutation was reported in all samples analyzed. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Laboratório Central do Amapá. Macapá, AP, Brasil. | pt_BR |
| Affilliation | Laboratório de Fronteira. Oiapoque, AP, Brasil. | pt_BR |
| Affilliation | Rio-Laranjeiras Hospital. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffreé Guinle. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro. RJ, Brasil. | pt_BR |
| Affilliation | Rio-Laranjeiras Hospital. Rio de Janeiro, RJ, Brasil | pt_BR |
| Subject | Chikungunya virus | pt_BR |
| Subject | Surveillance | pt_BR |
| Subject | co-infection | pt_BR |
| Subject | ECSA genotype | pt_BR |
| Subject | Asian genotype | pt_BR |
| Subject | Brazil | pt_BR |
| e-ISSN | 1999-4915 | |
