| Author | Kikuti, Mariana | |
| Author | Cardoso, Cristiane Wanderley | |
| Author | Prates, Ana P. B. | |
| Author | Paploski, Igor Adolfo Dexheimer | |
| Author | Kitron, Uriel | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Mochida, Ganeshwaran H. | |
| Author | Ribeiro, Guilherme de Sousa | |
| Access date | 2019-02-01T13:32:55Z | |
| Available date | 2019-02-01T13:32:55Z | |
| Document date | 2018 | |
| Citation | KIKUTI, M. et al. Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016. Euro Surveillance, v. 23, n. 45, p. 1-10, 2018. | pt_BR |
| ISSN | 1560-7917 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31375 | |
| Sponsorship | The Brazilian National Council of Technological and Scientific
Development, the Brazilian Coordination for the Improvement
of Higher Education, the Bahia Foundation for Research
Support, the National Institute of Neurological Disease and
Stroke, the Manton Center for Orphan Disease Research,
Boston Children’s Hospital Faculty Career Development
Award and the David Rockefeller Center for Latin American
Studies at Harvard University. | pt_BR |
| Language | eng | pt_BR |
| Publisher | European Centre for Disease Prevention and Control | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Zika virus | pt_BR |
| Subject in Portuguese | Microcefalia | pt_BR |
| Subject in Portuguese | Anomalia | pt_BR |
| Subject in Portuguese | Infecção | pt_BR |
| Subject in Portuguese | Gravidez | pt_BR |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Subject in Portuguese | Perímetro cefálico | pt_BR |
| Subject in Portuguese | Nascidos vivos | pt_BR |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Malformações congenitas | pt_BR |
| Title | Congenital brain abnormalities during a Zika virus epidemic in Salvador, Brazil, April 2015 to July 2016 | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.2807/1560-7917.ES.2018.23.45.1700757 | pt_BR |
| Abstract | North-eastern Brazil was the region most
affected by the outbreak of congenital Zika syndrome
that followed the 2015 Zika virus (ZIKV) epidemics,
with thousands of suspected microcephaly cases
reported to the health authorities, mostly between
late 2015 and early 2016. Aim: To describe clinical
and epidemiological aspects of the outbreak of congenital
brain abnormalities (CBAs) and to evaluate
the accuracy of different head circumference screening
criteria in predicting CBAs. Method: Between April
2015 and July 2016, the Centers for Information and
Epidemiologic Surveillance of Salvador, Brazil investigated
the reported cases suspected of microcephaly
and, based on intracranial imaging studies, confirmed
or excluded a diagnosis of CBA. Sensitivity, specificity
and positive and negative predictive values of different
head circumference screening criteria in predicting
CBAs were calculated. Results: Of the 365 investigated
cases, 166 (45.5%) had confirmed CBAs. The most
common findings were intracranial calcifications and
ventriculomegaly in 143 (86.1%) and 111 (66.9%) of
the 166 CBA cases, respectively. Prevalence of CBAs
peaked in December 2015 (2.24 cases/100 live births).
Cases of CBAs were significantly more likely to have
been born preterm and to mothers who had clinical
manifestations of arboviral infection during pregnancy.
None of the head circumference screening criteria performed
optimally in predicting CBAs. Conclusion: This
study highlights the magnitude of neurological consequences
of the ZIKV epidemic and the limitations of
head circumference in accurately identifying children
with CBA. Gestational symptoms compatible with ZIKV
infection should be combined with imaging studies
for efficient detection of suspect CBAs during ZIKV
epidemics. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Secretaria Municipal de Saúde de Salvador. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Emory University. Atlanta, United States. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Boston Children’s Hospital. Boston, United States / Massachusetts General Hospital. Boston, United States / Harvard Medical School. Boston, United States. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil. | pt_BR |
| Subject | Zika virus | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Abnormalities | pt_BR |
| Subject | Infection | pt_BR |
| Subject | Pregnancy | pt_BR |
| Subject | Epidemiology | pt_BR |
| Subject | Circumference screening | pt_BR |
| Subject | Live births | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Congenital malformations | pt_BR |
