Author | Pembrey, Lucy | |
Author | Barreto, Maurício Lima | |
Author | Douwes, Jeroen | |
Author | Cooper, Philip | |
Author | Henderson, John | |
Author | Mpairwe, Harriet | |
Author | Garcia, Cristina Ardura | |
Author | Chico, Martha | |
Author | Brooks, Collin | |
Author | Cruz Filho, Alvaro Augusto Souza da | |
Author | Elliott, Alison M. | |
Author | Figueiredo, Camila Alexandrina Viana de | |
Author | Langan, Sinéad M. | |
Author | Nassanga, Beatrice | |
Author | Ring, Susan | |
Author | Rodrigues, Laura Cunha | |
Author | Pearce, Neil | |
Access date | 2019-02-06T13:22:19Z | |
Available date | 2019-02-06T13:22:19Z | |
Document date | 2018 | |
Citation | PEMBREY, Lucy et al. Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration. ERJ Open Research, v. 4, p. 1-11, 2018. | pt_BR |
ISSN | 2312-0541 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/31451 | |
Sponsorship | Asthma Phenotypes study which is funded by the European Research
Council (ERC) under the European Union’s Seventh Framework Programme (FP7/2007-2013) with ERC grant agreement number 668954. S.M. Langan is supported by a Wellcome Trust senior research fellowship in clinical science (205039/Z/16/Z). The Centre for Global Chronic Conditions (formerly the Centre for Global NCDs) at the London School of Hygiene and Tropical Medicine is supported by the Wellcome Trust Institutional Strategic Support Fund (097834/Z/11/B). The Centre for Public Health Research is supported by grants from the New Zealand Health Research Council. The ALSPAC study receives core support from the UK Medical Research Council, the Wellcome Trust (grant reference: 102215/2/13/2) and the University of Bristol. Funding information for this article has been deposited with the Crossref Funder Registry. | pt_BR |
Language | eng | pt_BR |
Publisher | European Respiratory Society | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Asma | pt_BR |
Subject in Portuguese | Fenotipo | pt_BR |
Subject in Portuguese | Biomarcadores | pt_BR |
Subject in Portuguese | Fatores de risco | pt_BR |
Subject in Portuguese | Tratamento | pt_BR |
Subject in Portuguese | Prevenção | pt_BR |
Subject in Portuguese | Protocolo de pesquisa | pt_BR |
Subject in Portuguese | Colaboração | pt_BR |
Title | Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration | pt_BR |
Type | Article | pt_BR |
DOI | 10.1183/23120541.00013-2018 | |
Abstract | The World Asthma Phenotypes (WASP) study started in 2016 and has been conducted in five centres, in the UK, New Zealand, Brazil, Ecuador and Uganda. The objectives of this study are to combine detailed biomarker and clinical information in order to 1) better understand and characterise asthma phenotypes in high-income countries (HICs) and low and middle-income countries (LMICs), and in high and low prevalence centres; 2) compare phenotype characteristics, including clinical severity; 3) assess the risk factors for each phenotype; and 4) assess how the distribution of phenotypes differs between high prevalence and low prevalence centres. Here we present the rationale and protocol for the WASP study to enable other centres around the world to carry out similar analyses using a standardised protocol. Large collaborative and integrative studies like this are essential to further our understanding of asthma phenotypes. The findings of this study will help elucidate the aetiological mechanisms of asthma and might potentially identify new causes and guide the development of new treatments, thereby enabling better management and prevention of asthma in both HICs and LMICs. | pt_BR |
Affilliation | London School of Hygiene and Tropical Medicine. London, United Kingdom. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. | pt_BR |
Affilliation | Massey University. Centre for Public Health Research Wellington. New Zealand. | pt_BR |
Affilliation | St George’s University of London. London, UK / Universidad Internacional del Ecuador. Quito, Ecuador / Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador. | pt_BR |
Affilliation | University of Bristol. Bristol Medical School. Population Health Sciences. Bristol, UK. | pt_BR |
Affilliation | Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda. | pt_BR |
Affilliation | Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador. | pt_BR |
Affilliation | Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador. | pt_BR |
Affilliation | Massey University. Centre for Public Health Research Wellington. New Zealand. | pt_BR |
Affilliation | Federal University of Bahia. The Programme for Control of Asthma and Allergic Rhinitis. Salvador, BA, Brazil / Federal University of Bahia. Institute for Health Sciences. Salvador, BA, Brazil. | pt_BR |
Affilliation | Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
Affilliation | London School of Hygiene and Tropical Medicine. London, United Kingdom. | pt_BR |
Affilliation | Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda. | pt_BR |
Affilliation | University of Bristol. Bristol Medical School. Population Health Sciences. Bristol, UK. | pt_BR |
Affilliation | London School of Hygiene and Tropical Medicine. London, United Kingdom. | pt_BR |
Affilliation | London School of Hygiene and Tropical Medicine. London, United Kingdom / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil. | pt_BR |
Subject | Asthma | pt_BR |
Subject | Phenotypes | pt_BR |
Subject | Biomarkers | pt_BR |
Subject | Risk factors | pt_BR |
Subject | Treatment | pt_BR |
Subject | Prevention | pt_BR |
Subject | Protocols | pt_BR |
Subject | Collaboration | pt_BR |