| Author | Silva, Monaíse Madalena Oliveira | |
| Author | Tauro, Laura Beatriz | |
| Author | Kikuti, Mariana | |
| Author | Anjos, Rosângela Oliveira dos | |
| Author | Santos, Viviane Corrêa | |
| Author | Gonçalves, Thaiza Soares Ferreira | |
| Author | Paploski, Igor Adolfho Dexheimer | |
| Author | Moreira, Patrícia Sousa dos Santos | |
| Author | Nascimento, Leile Camila Jacob | |
| Author | Campos, Gúbio Soares | |
| Author | Ko, Albert Icksang | |
| Author | Weaver, Scott C | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Kitron, Uriel | |
| Author | Ribeiro, Guilherme de Sousa | |
| Access date | 2019-02-07T18:28:23Z | |
| Available date | 2019-02-07T18:28:23Z | |
| Document date | 2018 | |
| Citation | SILVA, Monaíse Madalena Oliveira et al. Concomitant transmission of dengue, chikungunya and Zika viruses in Brazil: Clinical and epidemiological findings from surveillance for acute febrile illness. Clinical of Infectious Diseases, p. 1-24, Dec. 18. 2018. | |
| ISSN | 1058-4838 | |
| URI | https://www.arca.fiocruz.br/handle/icict/31486 | |
| Sponsorship | Brazilian National Council for Scientific and Technological Development [grants 400830/2013-2, and 440891/2016-7 to G.S.R.; and scholarships to I.A.D.P., L.B.T., U.K., M.G.R., and G.S.R.]; the Bahia Foundation for Research Support [PET0026/2013, APP0044/2016, and PET0022/2016 to G.S.R., and scholarship to M.M.O.S.]; the Coordination for the Improvement of Higher Education Personnel, Brazilian Ministry of Education [440891/2016-7 to G.S.R. and scholarship to M.K.]; the National Institutes of Health (USA) [R01 TW009504, R01 AI121207, and U01 AI088752 to A.I.K.], [R24 AI AI120942 to SCW]; the Yale School of Public Health; the Federal University of Bahia; and the Oswaldo Cruz. | |
| Language | eng | en_US |
| Publisher | Oxford University Press | |
| Rights | open access | |
| Subject in Portuguese | Vírus da dengue | pt_BR |
| Subject in Portuguese | Vírus chikungunya | pt_BR |
| Subject in Portuguese | Vírus zika | pt_BR |
| Subject in Portuguese | Arbovírus | pt_BR |
| Subject in Portuguese | Co-infecção | pt_BR |
| Title | Concomitant transmission of dengue, chikungunya and Zika viruses in Brazil: Clinical and epidemiological findings from surveillance for acute febrile illness | en_US |
| Type | Preprint | |
| DOI | 10.1093/cid/ciy1083 | |
| Abstract | Since their emergence in the Americas, chikungunya (CHIKV) and Zika (ZIKV) viruses co-circulate with dengue virus (DENV), hampering clinical diagnosis. We investigated clinical and epidemiological characteristics of arboviral infections during the introduction and spread of CHIKV and ZIKV through northeastern Brazil. Methods. Surveillance for arboviral diseases among febrile patients was performed at an emergency health unit of Salvador, Brazil between Sep/2014-Jul/2016. We interviewed patients to collect data on symptoms, reviewed medical records to obtain the presumptive diagnoses, and performed molecular and serological testing to confirm DENV, CHIKV, ZIKV, or non-specific flavivirus (FLAV) diagnosis. Results. Of 948 participants, 247 (26.1%) had an acute infection, of which 224 (23.6%) were single infections (DENV: 32, or 3.4%; CHIKV: 159, 16.7%; ZIKV: 13, 1.4%; and FLAV: 20, 2.1%), and 23 (2.4%) co-infections (DENV/CHIKV: 13, 1.4%; CHIKV/FLAV: 9, 0.9%; and DEN/ZIKV: 1, 0.1%). An additional 133 (14.0%) patients had serological evidence for a recent arboviral infection. Patients with Zika presented rash (69.2%) and pruritus (69.2%) more frequently than those with dengue (37.5% and 31.2%, respectively) and chikungunya (22.9% and 14.7%, respectively) (P<0.001 for both comparisons). Conversely, arthralgia was more common in chikungunya (94.9%) and FLAV/CHIKV (100.0%) than in dengue (59.4%) and Zika (53.8%) (P<0.001). A correct presumptive clinical diagnosis was made for 9-23% of the confirmed patients. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto Nacional de Medicina Tropical. Puerto Iguazú, Argentina. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / University of Minnesota. USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. New Haven, USA. | |
| Affilliation | University of Texas Medical Branch. Galveston, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Emory University. Atlanta, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil. | |
| Subject | Dengue virus | en_US |
| Subject | Chikungunya virus | en_US |
| Subject | Zika virus | en_US |
| Subject | Arbovirus | en_US |
| Subject | Co-infection | en_US |
