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dc.contributor.authorSilva, Luciete A.
dc.contributor.authorCoronato, Beatriz
dc.contributor.authorCosta, Filipe A. Carvalho
dc.contributor.authorMúltipla autoria - ver em Notas
dc.identifier.citationSILVA, Luciete A. et al. Neisseria meningitidis disease-associated clones in Amazonas State, Brazil. Infectious Diseases, v. 50, n. 9, p. 697-704, 2018.
dc.descriptionAUTHORS - Luciete A. Silva a, Beatriz Coronato b, Jessica Schlackman c, Jane W. Marsh c, Chinelo Ezeonwuka c, Andréia b C. L. Fernandes b, Victor C. Souza a, Lirna S. da Silva a, Elaine F. Q. de Amorim a, Felipe G. Naveca a, Bernardino C. de Albuquerque d, Alcirene Amaral d, Ana L. S. Souza d, Filipe A. Carvalho-Costa b,e, Mustapha M. Mustapha c, Lee H. Harrison c and David E. Barrosob - AFFILIATIONS - aLaboratory of Microbial Diversity of Importance to Health and Laboratory of Communicable Disease Ecology, Le^onidas & Maria Deane Institute, FIOCRUZ, Manaus, Brazil; bLaboratory of Epidemiology and Molecular Systematics, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil; cInfectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, USA; dDepartment of Epidemiological Surveillance and Central Laboratory, Foundation of Health Surveillance of Amazonas, Manaus, AM, Brazil; eRegional Technical Office, FIOCRUZ, Teresina, Brazil.
dc.publisherTaylor & Francis
dc.rightsopen access
dc.subject.otherNeisseria meningitidis
dc.subject.otherDoença meningocócica
dc.subject.otherVacina conjugada sorogrupo C
dc.subject.otherClones MLST
dc.titleNeisseria meningitidis disease-associated clones in Amazonas State, Brazil
dc.description.abstractenBackground: The aim of this study is to describe the molecular epidemiology of Neisseria meningitidis invasive disease before the introduction of serogroup C conjugate vaccine in Amazonas State in 2010. Methods: Meningococcal disease reported cases were investigated in Amazonas State during the period 2000–2010. N. meningitidis isolates (n¼196) recovered from patients were genotyped by multilocus sequence typing (MLST) and sequencing of porB, porA, fetA, fHbp and penA. Antimicrobial susceptibility was determined using E-test. Results: In the study period, 948 cases were reported; the incidence was 2.8 for the entire state and 4.8 per 100,000 in the capital of Manaus. Most meningococcal disease was caused by N. meningitidis belonging to ST-32 (72%; 141/196) or ST-103 (21%; 41/196) clonal complexes. Capsular switching (B!C) was suggested within clonal complex (cc) 32. There were 6 (3%; 6/196) strains with intermediate susceptibility to penicillin and a single strain was resistant to rifampicin. Since 2007, serogroup C strains belonging to the cc103 have predominated and case-fatality has increased. Conclusion: We demonstrate a high rate of meningococcal disease in Amazonas State, where, like other parts of Brazil, serogroup C replaced serogroup B during 2000s. These data serve as a baseline to measure impact of serogroup C conjugate vaccine introduction in 2010. This study emphasizes the need for enhanced surveillance to monitor changes in meningococcal disease trends following the introduction of meningococcal vaccines.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Laboratório de Diversidade Microbiana de Importância para a Saúde. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis. Manaus, AM. Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil.
dc.creator.affilliationFundação Oswaldo Cruz. Escritório Regional. Teresina, PI, Brasil.
dc.creator.affilliationMúltipla autoria - ver em Notas
dc.subject.enNeisseria meningitidis
dc.subject.enSerogroup C conjugate vaccine
dc.subject.enMLST clones
Appears in Collections:PI - Artigos de Periódicos
AM - ILMD - Artigos de Periódicos
IOC - Artigos de Periódicos

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