| Author | Gervazoni, Luiza F. O. | |
| Author | Ozório, Gabriella Gonçalves | |
| Author | Amaral, Elmo E. Almeida | |
| Access date | 2019-02-12T12:35:14Z | |
| Available date | 2019-02-12T12:35:14Z | |
| Document date | 2018 | |
| Citation | GERVAZONI, Luiza F. O. et al. 2’-Hydroxyflavanone activity in vitro and in vivo against wild-type and antimony-resistant Leishmania amazonensis. PLoS Negl Trop Dis, v.12, n.12, e0006930, 18p, Dec. 2018. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31565 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Leishmania amazonensis | pt_BR |
| Subject in Portuguese | tividade de 2'-Hydroxyflavanone | pt_BR |
| Subject in Portuguese | In vitro | pt_BR |
| Subject in Portuguese | In vivo | pt_BR |
| Subject in Portuguese | Tipo selvagem | pt_BR |
| Subject in Portuguese | Resistencia ao antimônio | pt_BR |
| Title | 2'-Hydroxyflavanone activity in vitro and in vivo against wild-type and antimony-resistant Leishmania amazonensis | pt_BR |
| Type | Article | |
| DOI | 10.1371/journal.pntd.0006930 | |
| Abstract | To overcome the current problems in leishmaniasis chemotherapy, natural products have become an interesting alternative over the past few decades. Flavonoids have been studied as promising family of compounds for leishmaniasis treatment. 2'-Hydroxyflavanone (2HF) is a flavanone, a class of flavonoid that has shown promising results in cancer studies. In this study, we demonstrated the effects of 2HF in vitro and in vivo against wild-type and antimony-resistant Leishmania amazonensis promastigotes. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Leishmania amazonensis | pt_BR |
| Subject | 2’-Hydroxyflavanone activity | pt_BR |
| Subject | In vitro | pt_BR |
| Subject | In vivo | pt_BR |
| Subject | wild-type | pt_BR |
| Subject | antimony-resistant | pt_BR |
| e-ISSN | 1935-2735 | |
