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| Autor | Souza, Denise Andréa Silva de | |
| Autor | Pavoni, Daniela Parada | |
| Autor | Krieger, Marco Aurélio | |
| Autor | Ludwig, Adriana | |
| Fecha de acceso | 2019-02-15T18:18:59Z | |
| Fecha de disponibilización | 2019-02-15T18:18:59Z | |
| Fecha de publicación | 2018 | |
| Referencia | SOUZA, Denise Andréa Silva de et al. Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization. Scientific Reports, v. 8, n. 1376, p. 1-11, 2018. | pt_BR |
| ISSN | 2045-2322 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31696 | |
| Idioma | por | pt_BR |
| Editor | Nature Research | pt_BR |
| Derechos de autor | open access | pt_BR |
| Palabras clave en Portugués | Kinetoplastida | pt_BR |
| Título | Evolutionary analyses of myosin genes in trypanosomatids show a history of expansion, secondary losses and neofunctionalization | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1038/s41598-017-18865-y | |
| Resumen en Inglés | Myosins are motor proteins that comprise a large and diversified family important for a broad range of functions. Two myosin classes, I and XIII, were previously assigned in Trypanosomatids, based mainly on the studies of Trypanosoma cruzi, T. brucei and Leishmania major, and important human pathogenic species; seven orphan myosins were identified in T. cruzi. Our results show that the great variety of T. cruzi myosins is also present in some closely related species and in Bodo saltans, a member of an early divergent branch of Kinetoplastida. Therefore, these myosins should no longer be considered "orphans". We proposed the classification of a kinetoplastid-specific myosin group into a new class, XXXVI. Moreover, our phylogenetic data suggest that a great repertoire of myosin genes was present in the last common ancestor of trypanosomatids and B. saltans, mainly resulting from several gene duplications. These genes have since been predominantly maintained in synteny in some species, and secondary losses explain the current distribution. We also found two interesting genes that were clearly derived from myosin genes, demonstrating that possible redundant or useless genes, instead of simply being lost, can serve as raw material for the evolution of new genes and functions. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil. / Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil. | pt_BR |
| Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Genômica Funcional. Curitiba, PR, Brasil. / Instituto de Biologia Molecular do Paraná. Curitiba, PR, Brasil. | pt_BR |
| Palavras clave en Inglês | Trypanosoma cruzi | pt_BR |
| Palavras clave en Inglês | Myosins | pt_BR |
| Palavras clave en Inglês | Evolution | pt_BR |
| Palavras clave en Inglês | Molecular | pt_BR |
| Palavras clave | Evolución Molecular | pt_BR |
| DeCS | Miosinas | pt_BR |
| DeCS | Trypanosomatina | pt_BR |
| DeCS | Evolução Molecular | pt_BR |
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