| Author | Carvalho, Renato L. de | |
| Author | Jardim, Guilherme A. M. | |
| Author | Santos, Augusto C. C. | |
| Author | Araujo, Maria H. | |
| Author | Oliveira, Willian X. C. | |
| Author | Bombaça, Ana Cristina S. | |
| Author | Menna-Barreto, Rubem F. S. | |
| Author | Gopi, Elumalai | |
| Author | Gravel, Edmond | |
| Author | Doris, Eric | |
| Author | Silva Júnior, Eufrânio N. da | |
| Access date | 2019-02-18T16:48:56Z | |
| Available date | 2019-02-18T16:48:56Z | |
| Document date | 2018 | |
| Citation | CARVALHO, Renato L. de et al. Combination of Aryl Diselenides/Hydrogen Peroxide and CarbonNanotube/Rhodium Nanohybrids for Naphthol Oxidation: An Efficient Route towards Trypanocidal Quinones. Chem. Eur. J., v. 24, p. 15227-15235, 2018. | pt_BR |
| ISSN | 1521-3765 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31711 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Quinonas Tripanocidas | pt_BR |
| Subject in Portuguese | Deselenídeos de Arilo | pt_BR |
| Subject in Portuguese | Nano-Carbono de Carbono | pt_BR |
| Subject in Portuguese | Nano-Híbridos de Ródio | pt_BR |
| Subject in Portuguese | Oxidação de Naftol: | pt_BR |
| Subject in Portuguese | Peróxido de Hidrogênio | pt_BR |
| Title | Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon-Nanotube/Rhodium Nanohybrids for Naphthol Oxidation: An Efficient Route towards Trypanocidal Quinones | pt_BR |
| Type | Article | |
| DOI | 10.1002/chem.201802773 | |
| Abstract | This work reports a combination of aryl diselenides/hydrogen peroxide and carbon-nanotube (CNT)/rhodium nanohybrids (RhCNT) for naphthol oxidation towards the synthesis of 1,4-naphthoquinones and evaluation of their relevant trypanocidal activity. Under a combination of (PhSe)2 /H2 O2 in the presence of O2 in iPrOH/hexane, several benzenoid (A-ring)-substituted quinones were prepared in moderate to high yields. We also studied the contribution of RhCNT as co-catalyst in this process and, in some cases, yields were improved. This method provides an efficient and versatile alternative for preparing A-ring-modified naphthoquinonoid compounds with relevant biological profile. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Université Paris-Saclay. Service d eChimie Bioorganique et de Marquage. Gif-sur-Yvette. France. | pt_BR |
| Affilliation | Université Paris-Saclay. Service d eChimie Bioorganique et de Marquage. Gif-sur-Yvette. France. | pt_BR |
| Affilliation | Université Paris-Saclay. Service d eChimie Bioorganique et de Marquage. Gif-sur-Yvette. France. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Trypanocidal Quinones | pt_BR |
| Subject | Aryl Diselenides | pt_BR |
| Subject | Hydrogen Peroxide | pt_BR |
| Subject | CarbonNanotube | pt_BR |
| Subject | Rhodium Nanohybrids | pt_BR |
| Subject | Naphthol Oxidation | pt_BR |
| Embargo date | 2022-01-01 | |
