| Author | Almeida-Paes, Rodrigo | |
| Author | Almeida-Silva, Fernando | |
| Author | Pinto, Gabriela Costa Maia | |
| Author | Almeida, Marcos de Abreu | |
| Author | Muniz, Mauro de Medeiros | |
| Author | Pizzini, Claudia Vera | |
| Author | Gerfen, Gary J. | |
| Author | Nosanchuk, Joshua Daniel | |
| Author | Zancopé-Oliveira, Rosely Maria | |
| Access date | 2019-02-19T11:33:42Z | |
| Available date | 2019-02-19T11:33:42Z | |
| Document date | 2018 | |
| Citation | ALMEIDA-PAES, Rodrigo et al. L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum. Medical Mycology, v. 56, 506–509, 2018. | pt_BR |
| ISSN | 1369-3786 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/31723 | |
| Language | eng | pt_BR |
| Publisher | Oxford University Press | pt_BR |
| Rights | open access | pt_BR |
| Title | L-tyrosine induces the production of a pyomelanin-like pigment by the parasitic yeast-form of Histoplasma capsulatum | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1093/mmy/myx068 | |
| Abstract | Melanization of Histoplasma capsulatum remains poorly described, particularly in regards to the forms of melanin produced. In the present study, 30 clinical and environmental H. capsulatum strains were grown in culture media with or without L-tyrosine under conditions that produced either mycelial or yeast forms. Mycelial cultures were not melanized under the studied conditions. However, all strains cultivated under yeast conditions produced a brownish to black soluble pigment compatible with pyomelanin when grew in presence of L-tyrosine. Sulcotrione inhibited pigment production in yeast cultures, strengthening the hyphothesis that H. capsulatum yeast forms produce pyomelanin. Since pyomelanin is produced by the fungal parasitic form, this pigment may be involved in H. capsulatum virulence. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Albert Einstein College of Medicine. Department of Physiology and Biophysics. New York, NY, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Histoplasma capsulatum | pt_BR |
| Subject | L-tyrosine | pt_BR |
| Subject | Pyomelanin | pt_BR |
| e-ISSN | 1460-2709 | |
| Embargo date | 2020-01-31 | |
